Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dobutamine | increases pyruvate dehydrogenase complex activity | Sus scrofa | |
additional information | enzyme complex activity is increased with high workload and energy expenditure in the myocardium | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Sus scrofa | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sus scrofa | regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview | ? | - |
? | |
pyruvate + CoA + NAD+ | Sus scrofa | - |
acetyl-CoA + CO2 + NADH | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | regulation of pyruvate dehydrogenase complex activity through reversible phosphorylation | Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Sus scrofa | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
measurement of NADH/NAD+ and acetyl-CoA/CoA ratios, and citric acid cycle intermediates in blood and tissue, measurement of O2-uptake and fatty acid and glucose oxidation level | Sus scrofa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | regulation of pyruvate dehydrogenase complex activity and citric acid cycle intermediates during high cardiac power generation, inhibition of fatty acid oxidation has a regulatory function, overview | Sus scrofa | ? | - |
? | |
pyruvate + CoA + NAD+ | - |
Sus scrofa | acetyl-CoA + CO2 + NADH | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
PDH | - |
Sus scrofa |
pyruvate dehydrogenase complex | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Sus scrofa |