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Literature summary for 1.17.4.4 extracted from

  • Tie, J.K.; Jin, D.Y.; Stafford, D.W.
    Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration (2014), J. Biol. Chem., 289, 9396-9407 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.17.4.4

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane VKORC1L1 is a four-transmembrane domain protein with both its termini located in the cytoplasm Homo sapiens 16020
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N0U8
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Synonyms

Synonyms Comment Organism
VKORC1-like 1
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 Homo sapiens
VKORC1L1
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 Homo sapiens

General Information

General Information Comment Organism
metabolism in vivo VKORC1L1 reduces vitamin K epoxide to support vitamin K-dependent carboxylation as efficiently as does VKORC1 Homo sapiens
additional information the conserved loop cysteines of VKORC1L1, but not VKORC1, are involved in active site regeneration through an intra-molecular pathway. The different structures and reaction mechanisms of VKORC1L1 and VKORC1 may imply that these two enzymes have different physiological functions Homo sapiens