show all | hide all No of entries

Information on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

for references in articles please use BRENDA:EC1.17.4.4
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol.
Specify your search results
Select one or more organisms in this record: ?
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
a protein with a disulfide bond
+
=
+
a protein with reduced L-cysteine residues
+
a protein with a disulfide bond
=
+
a protein with reduced L-cysteine residues
Synonyms
vkorc1, vitamin k epoxide reductase, vkorc1l1, vitamin k 2,3-epoxide reductase, vkorc1v2, vitamin k-epoxide reductase, vitamin k oxidoreductase, vitamin k1 epoxide reductase, vkor complex, vkorc1-like 1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues
show the reaction diagram
(2)
-
-
0
phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues
show the reaction diagram