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Information on EC 1.17.4.4 - vitamin-K-epoxide reductase (warfarin-sensitive)

for references in articles please use BRENDA:EC1.17.4.4
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IUBMB Comments
The enzyme catalyses the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, peptidyl-glutamate 4-carboxylase, back to its phylloquinol active form. The enzyme forms a tight complex with EC 5.3.4.1, protein disulfide-isomerase, which transfers the required electrons from newly-synthesized proteins by catalysing the formation of disulfide bridges. The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2). Inhibited strongly by (S)-warfarin and ferulenol.
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Reaction Schemes
+
a protein with a disulfide bond
+
=
+
a protein with reduced L-cysteine residues
+
a protein with a disulfide bond
=
+
a protein with reduced L-cysteine residues
Synonyms
phylloquinone epoxide reductase, reductase, phylloquinone epoxide, vitamin K 2,3-epoxide reductase, vitamin K 2,3-epoxide reductase complex subunit 1, vitamin K 2,3-epoxide reductase complex subunit-1, vitamin K epoxid reductase, vitamin K epoxide reductase, vitamin K epoxide reductase complex subunit 1, vitamin K oxidoreductase, Vitamin K reductase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues
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(2)
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phylloquinone + a protein with a disulfide bond + H2O = 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues
show the reaction diagram