Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of XDH-knockdown mutants, analysis of compromised drought-stress responses of proline biosynthesis in Arabidopsis thaliana XDH-knockdown mutants, phenotype, overview | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + NAD+ + H2O | Arabidopsis thaliana | - |
urate + NADH + H+ | - |
? | |
xanthine + NAD+ + H2O | Arabidopsis thaliana Col-0 | - |
urate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q8GUQ8 | - |
- |
Arabidopsis thaliana Col-0 | Q8GUQ8 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
xanthine + NAD+ + H2O | - |
Arabidopsis thaliana | urate + NADH + H+ | - |
? | |
xanthine + NAD+ + H2O | - |
Arabidopsis thaliana Col-0 | urate + NADH + H+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
malfunction | dysfunction of purine degradation is a result of knocking down the key enzyme xanthine dehydrogenase, leading to severely reduced survival of Arabidopsis thaliana under progressive drought conditions and to significantly decreased tolerance to superoxide-mediated oxidative stress. The enhanced stress sensitivity of the knockdown mutants likely results from defective stress responses, because the drought-induced accumulation of the cellular protectant proline is compromised in the knockdown plants, which also show lower mRNA levels of P5CS1, the gene encoding the rate-limiting enzyme for proline biosynthesis, DELTA1-pyrroline-5-carboxylate synthase 1 | Arabidopsis thaliana |
physiological function | role for purine metabolites in stress responses, supporting the possible contribution of purine degradation to plant acclimation to changing environments, overview | Arabidopsis thaliana |