Application | Comment | Organism |
---|---|---|
medicine | homology modelling of the enzyme cytochrome P450 17alpha-hydroxylase/17,20-lyase (P450c17)-a target for prostate cancer chemotherapy-from the crystal structure of P450BM-3 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ketoconazole | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17alpha-Hydroxypregnenolone | - |
Homo sapiens | Dehydroepiandrosterone + acetaldehyde | DHEA | ? | |
17alpha-hydroxyprogesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | androstenedione + acetate + [oxidized NADPH-hemoprotein reductase] + H2O | androstenedione | ? |