Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme expression is induced by cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene CYP7A1, genetic structure, the gene contains six exons and five introns and is located on chromosome 8 at 8q11-q12, CYP7A1 mRNA levels are regulated through the farnesoid X receptor and the liver X receptor by many stimuli including cholesterol, bile acids, cytokines, steroid hormones, and thyroid hormone | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A204C | nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene, the genetic variant shows less total cholesterol level decrease in response to dietary changes in different types of dietary intervention studies compared to C204 homozygotes, overview | Homo sapiens |
A278C | nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene | Homo sapiens |
C554T | nucleotide exchange, a naturally occuring promoter polymorphism in the CYP7A1 gene | Homo sapiens |
additional information | genotyping and frequency of polymorphisms in human populations, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22680 | gene CYP7A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview | Homo sapiens | 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 7alpha-hydroxylase | - |
Homo sapiens |
CYP7A1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |