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Information on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase

for references in articles please use BRENDA:EC1.14.14.23
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IUBMB Comments
A P-450 heme-thiolate liver protein that catalyses the first step in the biosynthesis of bile acids. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH---hemoprotein reductase.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cyp7a1, cholesterol 7 alpha-hydroxylase, cholesterol 7alpha-hydroxylase, 7alpha-hydroxylase, cyp7a, hepatic cholesterol 7alpha-hydroxylase, cholesterol 7-alpha hydroxylase, cholesterol 7-alpha-hydroxylase, c7alphaoh, cholesterol 7alpha hydroxylase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
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