Application | Comment | Organism |
---|---|---|
agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Oculimacula yallundae |
agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Blumeria graminis |
agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Oculimacula acuformis |
agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Zymoseptoria tritici |
medicine | the enzyme is a target for antifungal inhibitors | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
F180L | the naturally occuring mutation is responsible for the resistance to triazoles | Oculimacula acuformis |
I381V | the naturally occuring mutation causes resistance against triazole inhibitors epoxiconazole and tebuconazole | Zymoseptoria tritici |
additional information | the enzyme shows a number of polymorphisms at the amino acid level | Oculimacula yallundae |
additional information | the enzyme shows a number of polymorphisms at the amino acid level | Oculimacula acuformis |
Y136F | a naturally occuring mutation in both wheat and barley powdery mildew that leads to resistance or low sensitivity against triazole | Blumeria graminis |
Y136F/K147Q | a naturally occuring double mutation in barley powdery mildew that leads to high resistance against triazole | Blumeria graminis |
Y137F | the naturally occuring mutation does not affect triazole sensitivity | Zymoseptoria tritici |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
azole | the organism shows reduced azole-sensitivity | Zymoseptoria tritici | |
epoxiconazole | - |
Zymoseptoria tritici | |
imidazoles | - |
Oculimacula acuformis | |
imidazoles | - |
Oculimacula yallundae | |
additional information | the enzyme is highly resistant to triadimenol | Blumeria graminis | |
additional information | Oculimacula acuformis is intrinsically resistant to triazoles and sensitive to imidazoles | Oculimacula acuformis | |
Prochloraz | - |
Oculimacula yallundae | |
prothioconazole | - |
Zymoseptoria tritici | |
tebuconazole | - |
Zymoseptoria tritici | |
triazole | - |
Blumeria graminis | |
triazole | sensitive and resistant variants of CYP51A1, mutations lead to alterations in the enzyme as drug target, primary determinants of triazole resistance, overview | Candida albicans | |
triazoles | - |
Oculimacula yallundae | |
triazoles | - |
Zymoseptoria tritici |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Blumeria graminis | - |
f. sp. hordei or f. sp. tritici, barley or wheat powdery mildew, gene CYP51 | - |
Candida albicans | - |
- |
- |
Oculimacula acuformis | - |
syn. Tapesia acuformis, cereal eyespot fungi, gene CYP51 | - |
Oculimacula yallundae | - |
syn. Tapesia yallundae, cereal eyespot fungi, gene CYP51 | - |
Zymoseptoria tritici | - |
septoria leaf blotch fungus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | residues Ile381 and Leu321 are involved in substrate recognition | Zymoseptoria tritici | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP51 | - |
Candida albicans |
CYP51 | - |
Oculimacula yallundae |
CYP51 | - |
Blumeria graminis |
CYP51 | - |
Oculimacula acuformis |
CYP51 | - |
Zymoseptoria tritici |
cytochrome P450 sterol 14alpha-demethylase | - |
Candida albicans |