Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.14.14.154 - sterol 14alpha-demethylase

for references in articles please use BRENDA:EC1.14.14.154
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This cytochrome P-450 (heme-thiolate) enzyme acts on a range of steroids with a 14alpha-methyl group, such as obtusifoliol and lanosterol. The enzyme catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The enzyme appears in viruses and cellular organisms
Synonyms
cyp51, erg11, cyp51a, cyp51a1, erg11p, cyp51b, lanosterol 14alpha-demethylase, lanosterol 14 alpha-demethylase, lanosterol demethylase, sterol 14alpha-demethylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1c)
-
-
-
a 14alpha-hydroxymethylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-formylsteroid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
show the reaction diagram
(1b)
-
-
-
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
show the reaction diagram
a 14alpha-methylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-hydroxymethylsteroid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
(1a)
-
-
-