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Literature summary for 1.14.11.68 extracted from

  • Shpargel, K.B.; Starmer, J.; Yee, D.; Pohlers, M.; Magnuson, T.
    KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development (2014), PLoS Genet., 10, e1004507 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.68

Organism

Organism UniProt Comment Textmining
Mus musculus O70546 isoform Utx
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Mus musculus Q5NCY0 isoform Jmjd3
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Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
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fibroblast
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
JMJD3
-
 Mus musculus
KDM6A
-
 Mus musculus
KDM6B
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 Mus musculus
UTX
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 Mus musculus

General Information

General Information Comment Organism
physiological function male embryos lacking both H3K27 demethylases Jmjd3 and Utx survive to term. At mid-gestation, embryos demonstrate proper patterning and activation of Hox genes. The embryos retain the Y-chromosome UTtx homolog, UtyY, which cannot demethylate H3K27me3. Embryonic stem cells lacking both Jmjd3 and Utx exhibit a typical decrease in global H3K27me3 levels with differentiation. Retinoic acid differentiations of these embryonic stem cells demonstrate loss of H3K27me3 and gain of H3K4me3 to Hox promoters and other transcription factors, and induce expression similar to control cells. A small subset of genes exhibit decreased expression associated with reduction of promoter H3K4me3 and some low-level accumulation of H3K27me3. Utx and Jmjd3 mutant mouse embryonic fibroblasts demonstrate dramatic loss of H3K27me3 from promoters of several Hox genes and transcription factors Mus musculus