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Information on EC 1.14.11.68 - [histone H3]-trimethyl-L-lysine27 demethylase

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IUBMB Comments
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 27 of histone H3 (H3K27). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri- and di-methylated forms, but have no activity with the mono-methylated form.
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Word Map
  • 1.14.11.68
  • kabuki
  • polycomb
  • crebbp
  • smarca4
  • k-specific
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine27
+
2
+
2
=
a [histone H3]-N6-methyl-L-lysine27
+
2
+
2
+
2
Synonyms
JMJD3, KDM6A, KDM6C, UTX, UTY, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-N6-methyl-L-lysine27 + 2 succinate + 2 formaldehyde + 2 CO2
show the reaction diagram
overall reaction
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
(1a)
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a [histone H3]-N6,N6-dimethyl-L-lysine27 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine27 + succinate + formaldehyde + CO2
show the reaction diagram
(1b)
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