Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O70546 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C2C12 cell | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | demethylase UTX mediates removal of H3K27me3 at the Myog and CKm genes. Transactivator Six4 initially recruits UTX to the regulatory region of muscle genes. The resulting loss of H3K27me3 marks is limited to the region upstream of the transcriptional start site. Blocking polymerase Pol II elongation on transcribed genes leads to increased H3K27me3 within the coding region, and formation of bivalent (H3K27me3/H3K4me3) chromatin domains | Mus musculus |