Literature summary for 1.14.11.66 extracted from

Qi, Q.; Wang, Y.; Wang, X.; Yang, J.; Xie, Y.; Zhou, J.; Li, X.; Wang, B.
Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPalpha and canonical Wnt signaling (2020), Cell. Mol. Life Sci., 77, 2407-2421 .

Search for more literature for 1.14.11.66

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BW72	isoform KDM4A	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Mus musculus	-
ST-2 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
KDM4A	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	KDM4A is a epigenetic regulator of osteoblast and adipocyte differentiation. KDM4A expression is upregulated during osteogenesis and adipogenesis of primary marrow stromal cells and stromal ST2 line. Overexpression of wild-type KDM4A promotes adipogenic differentiation and blocks osteogenic differentiation of the progenitor cells. Depletion or inactivation of KDM4A in undifferentiated progenitor cells inhibits the formation of adipocytes and promotes the differentiation of osteoblasts. Overexpression of KDM4A upregulates the expression of secreted frizzled-related protein Sfrp4 and CCAAT/enhancer-binding protein C/ebpalpha. KDM4A directly binds the promoters of Sfrp4 and C/ebpalpha, removes the histone methylation mark H3K9me3, and reduces DNA methylation levels of CpG in promoter regions of C/ebpalpha and Sfrp4. Overexpression of KDM4A inactivates canonical Wnt signaling	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)