Literature summary for 1.14.11.66 extracted from

Li, M.; Cheng, J.; Ma, Y.; Guo, H.; Shu, H.; Huang, H.; Kuang, Y.; Yang, T.
The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling (2020), Cancer Cell Int., 20, 101 .

Search for more literature for 1.14.11.66

Application

Application	Comment	Organism
medicine	JMJD2A displays higher expression in glioma tissues than that in normal brain tissues and lower levels of H3K9me3/H3K36me3are found in glioma tissues	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75164	cf.EC 1.14.11.69	-

Synonyms

Synonyms	Comment	Organism
JMJD2A	-	Homo sapiens
KDM4A	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	JMJD2A displays higher expression in glioma tissues than that in normal brain tissues and lower levels of H3K9me3/H3K36me3are found in glioma tissues. Knockdown of JMJD2A expression attenuates the growth and colony formation in glioma cell lines U251, T98G, and U87MG, whereas JMJD2A overexpression results in opposing effects. JMJD2A knockdown reduces the growth of glioma T98G cells in vivo. JMJD2A activates the Akt-mTOR pathway and promotes protein synthesis in glioma cells via promoting phosphoinositide-dependent kinase-1 expression	Homo sapiens

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Release 2023.1 (January 2023)