Literature summary for 1.14.11.63 extracted from

Zhang, W.; Li, K.; Wang, T.; Wu, M.; Li, L.
Discovery of JMJD7 inhibitors with the aid of virtual screening and bioactivity evaluation (2021), Bioorg. Med. Chem. Lett., 45, 128139 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid	-	Homo sapiens
2-[3-(3,4-dimethoxyphenyl)propanamido]benzoic acid	-	Homo sapiens
3-amino-N-[3-(4-amino-4-methylcyclohexyl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]-2,3-dihydropyrazine-2-carboxamide	-	Homo sapiens
5-(1,3-benzothiazol-2-yl)-N-propylthiophene-2-carboxamide	-	Homo sapiens
7-[phenyl[(pyridin-2-yl)amino]methyl]quinolin-8-ol	-	Homo sapiens
ethyl 2-[[(4-nitrophenyl)methanesulfonyl]carbamoyl]pyridine-4-carboxylate	-	Homo sapiens
[8-[(2,4-dichlorobenzoyl)oxy]quinolin-5-yl]azinic acid	compound efficiently binds to JMJD7 in vitro. In a cellular assay, the compound displays good inhibitory activity against cancer cell lines expressing a high level of JMJD7	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P0C872	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0066	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[8-[(2,4-dichlorobenzoyl)oxy]quinolin-5-yl]azinic acid
0.0072	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	2-[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)carbamoyl]cyclopent-1-ene-1-carboxylic acid
0.011	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	5-(1,3-benzothiazol-2-yl)-N-propylthiophene-2-carboxamide
0.0282	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	ethyl 2-[[(4-nitrophenyl)methanesulfonyl]carbamoyl]pyridine-4-carboxylate
0.0316	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	7-[phenyl[(pyridin-2-yl)amino]methyl]quinolin-8-ol
0.0332	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	2-[3-(3,4-dimethoxyphenyl)propanamido]benzoic acid
0.0501	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	3-amino-N-[3-(4-amino-4-methylcyclohexyl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]-2,3-dihydropyrazine-2-carboxamide

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Release 2023.1 (January 2023)