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Information on EC 1.14.11.63 - peptidyl-lysine (3S)-dioxygenase

for references in articles please use BRENDA:EC1.14.11.63

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IUBMB Comments

Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
a [protein]-L-lysine
+
+
=
a [protein]-(3S)-3-hydroxy-L-lysine
+
+

Synonyms
JmjC domain-containing protein 7, JMJD7, Jumonji domain-containing protein 7, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
show the reaction diagram
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Highest Expressing Human Cell Lines
Cell Line Links Gene Links