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Information on EC 1.14.11.63 - peptidyl-lysine (3S)-dioxygenase

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IUBMB Comments
Requires iron(II). The enzyme acts on specific lysine residues in its substrates, and is stereo-specific. The enzyme encoded by the human JMJD7 gene acts specifically on two related members of the translation factor family of GTPases, DRG1 and DRG2.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
a [protein]-L-lysine
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a [protein]-(3S)-3-hydroxy-L-lysine
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Synonyms
JmjC domain-containing protein 7, JMJD7, Jumonji domain-containing protein 7, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
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