BRENDA - Enzyme Database show
show all sequences of 1.14.11.11

Hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, an alkaloid-producing root cultures

Hashimoto, T.; Yamada, Y.; Plant Physiol. 81, 619-625 (1986)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
acetone
10% v/v, activation
Atropa belladonna
acetone
10% v/v, activation
Datura metel
acetone
10% v/v, activation
Duboisia leichhardtii
acetone
10% v/v, activation
Hyoscyamus albus
acetone
10% v/v, activation
Hyoscyamus gyorffi
acetone
10% v/v, activation
Hyoscyamus muticus
acetone
10% v/v, activation
Hyoscyamus niger
acetone
10% v/v, activation
Hyoscyamus pusillus
ascorbate
required
Atropa belladonna
ascorbate
required
Datura metel
ascorbate
required
Duboisia leichhardtii
ascorbate
required
Hyoscyamus albus
ascorbate
required
Hyoscyamus gyorffi
ascorbate
required
Hyoscyamus muticus
ascorbate
required
Hyoscyamus niger
ascorbate
required
Hyoscyamus pusillus
catalase
activation
Atropa belladonna
catalase
activation
Datura metel
catalase
activation
Duboisia leichhardtii
catalase
activation
Hyoscyamus albus
catalase
activation
Hyoscyamus gyorffi
catalase
activation
Hyoscyamus muticus
catalase
activation
Hyoscyamus niger
catalase
activation
Hyoscyamus pusillus
dithiothreitol
activation
Atropa belladonna
dithiothreitol
activation
Datura metel
dithiothreitol
activation
Duboisia leichhardtii
dithiothreitol
activation
Hyoscyamus albus
dithiothreitol
activation
Hyoscyamus gyorffi
dithiothreitol
activation
Hyoscyamus muticus
dithiothreitol
activation
Hyoscyamus niger
dithiothreitol
activation
Hyoscyamus pusillus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.017
-
L-hyoscyamine
-
Hyoscyamus niger
0.057
-
2-oxoglutarate
-
Hyoscyamus niger
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
required
Atropa belladonna
Fe2+
required
Datura metel
Fe2+
required
Duboisia leichhardtii
Fe2+
required
Hyoscyamus albus
Fe2+
required
Hyoscyamus gyorffi
Fe2+
required
Hyoscyamus muticus
Fe2+
required
Hyoscyamus niger
Fe2+
required
Hyoscyamus pusillus
Organic Solvent Stability
Organic Solvent
Commentary
Organism
Acetone
10% v/v, activation
Atropa belladonna
Acetone
10% v/v, activation
Datura metel
Acetone
10% v/v, activation
Duboisia leichhardtii
Acetone
10% v/v, activation
Hyoscyamus albus
Acetone
10% v/v, activation
Hyoscyamus gyorffi
Acetone
10% v/v, activation
Hyoscyamus muticus
Acetone
10% v/v, activation
Hyoscyamus niger
Acetone
10% v/v, activation
Hyoscyamus pusillus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Atropa belladonna
-
-
-
Datura metel
-
-
-
Duboisia leichhardtii
-
-
-
Hyoscyamus albus
-
-
-
Hyoscyamus gyorffi
-
-
-
Hyoscyamus muticus
-
-
-
Hyoscyamus niger
-
-
-
Hyoscyamus pusillus
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Hyoscyamus niger
Source Tissue
Source Tissue
Commentary
Organism
Textmining
root
culture
Atropa belladonna
-
root
culture
Datura metel
-
root
culture
Duboisia leichhardtii
-
root
culture
Hyoscyamus albus
-
root
culture
Hyoscyamus gyorffi
-
root
culture
Hyoscyamus muticus
-
root
culture
Hyoscyamus niger
-
root
culture
Hyoscyamus pusillus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Atropa belladonna
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Atropa belladonna
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Duboisia leichhardtii
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Duboisia leichhardtii
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus muticus
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus muticus
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus pusillus
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus pusillus
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus albus
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus albus
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Datura metel
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Datura metel
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus gyorffi
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus gyorffi
?
L-hyoscyamine + 2-oxoglutarate + O2
only the L-isomer of hyoscyamine serves as substrate, D-hyoscyamine is nearly inactive
439277
Hyoscyamus niger
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus niger
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
acetone
10% v/v, activation
Atropa belladonna
acetone
10% v/v, activation
Datura metel
acetone
10% v/v, activation
Duboisia leichhardtii
acetone
10% v/v, activation
Hyoscyamus albus
acetone
10% v/v, activation
Hyoscyamus gyorffi
acetone
10% v/v, activation
Hyoscyamus muticus
acetone
10% v/v, activation
Hyoscyamus niger
acetone
10% v/v, activation
Hyoscyamus pusillus
ascorbate
required
Atropa belladonna
ascorbate
required
Datura metel
ascorbate
required
Duboisia leichhardtii
ascorbate
required
Hyoscyamus albus
ascorbate
required
Hyoscyamus gyorffi
ascorbate
required
Hyoscyamus muticus
ascorbate
required
Hyoscyamus niger
ascorbate
required
Hyoscyamus pusillus
catalase
activation
Atropa belladonna
catalase
activation
Datura metel
catalase
activation
Duboisia leichhardtii
catalase
activation
Hyoscyamus albus
catalase
activation
Hyoscyamus gyorffi
catalase
activation
Hyoscyamus muticus
catalase
activation
Hyoscyamus niger
catalase
activation
Hyoscyamus pusillus
dithiothreitol
activation
Atropa belladonna
dithiothreitol
activation
Datura metel
dithiothreitol
activation
Duboisia leichhardtii
dithiothreitol
activation
Hyoscyamus albus
dithiothreitol
activation
Hyoscyamus gyorffi
dithiothreitol
activation
Hyoscyamus muticus
dithiothreitol
activation
Hyoscyamus niger
dithiothreitol
activation
Hyoscyamus pusillus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.017
-
L-hyoscyamine
-
Hyoscyamus niger
0.057
-
2-oxoglutarate
-
Hyoscyamus niger
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
required
Atropa belladonna
Fe2+
required
Datura metel
Fe2+
required
Duboisia leichhardtii
Fe2+
required
Hyoscyamus albus
Fe2+
required
Hyoscyamus gyorffi
Fe2+
required
Hyoscyamus muticus
Fe2+
required
Hyoscyamus niger
Fe2+
required
Hyoscyamus pusillus
Organic Solvent Stability (protein specific)
Organic Solvent
Commentary
Organism
Acetone
10% v/v, activation
Atropa belladonna
Acetone
10% v/v, activation
Datura metel
Acetone
10% v/v, activation
Duboisia leichhardtii
Acetone
10% v/v, activation
Hyoscyamus albus
Acetone
10% v/v, activation
Hyoscyamus gyorffi
Acetone
10% v/v, activation
Hyoscyamus muticus
Acetone
10% v/v, activation
Hyoscyamus niger
Acetone
10% v/v, activation
Hyoscyamus pusillus
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Hyoscyamus niger
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
root
culture
Atropa belladonna
-
root
culture
Datura metel
-
root
culture
Duboisia leichhardtii
-
root
culture
Hyoscyamus albus
-
root
culture
Hyoscyamus gyorffi
-
root
culture
Hyoscyamus muticus
-
root
culture
Hyoscyamus niger
-
root
culture
Hyoscyamus pusillus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Atropa belladonna
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Atropa belladonna
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Duboisia leichhardtii
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Duboisia leichhardtii
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus muticus
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus muticus
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus pusillus
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus pusillus
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus albus
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus albus
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Datura metel
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Datura metel
?
L-hyoscyamine + 2-oxoglutarate + O2
-
439277
Hyoscyamus gyorffi
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus gyorffi
?
L-hyoscyamine + 2-oxoglutarate + O2
only the L-isomer of hyoscyamine serves as substrate, D-hyoscyamine is nearly inactive
439277
Hyoscyamus niger
6beta-hydroxyhyoscyamine + succinate + CO2
-
439277
Hyoscyamus niger
?
Other publictions for EC 1.14.11.11
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741836
Cardillo
-
Production of tropane alkaloi ...
Brugmansia x candida
Biochem. Eng. J.
125
180-189
2017
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1
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743509
Xia
Promoting scopolamine biosynt ...
Hyoscyamus niger
Plant Physiol. Biochem.
106
46-53
2016
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-
1
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5
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742949
Cao
Efficient biosynthesis of rar ...
Anisodus acutangulus
J. Biotechnol.
211
123-129
2015
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-
1
-
6
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2
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1
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3
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2
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1
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1
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6
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2
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1
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2
1
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1
1
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2
2
726207
Dehghan
An atypical pattern of accumul ...
Hyoscyamus senecionis
Plant Physiol. Biochem.
70
188-194
2013
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1
-
-
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1
1
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1
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6
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1
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1
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1
1
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6
-
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2
1
-
-
-
-
-
-
-
1
-
2
2
-
-
-
724556
Li
Functional characterization of ...
Atropa belladonna
Bioorg. Med. Chem.
20
4356-4363
2012
-
-
1
-
-
-
8
1
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2
2
-
1
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1
1
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2
5
1
1
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1
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1
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8
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1
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2
2
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1
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2
5
1
1
-
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1
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-
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-
1
1
-
-
-
725946
Kai
Enhancing the production of tr ...
Anisodus acutangulus
Mol. Biosyst.
8
2883-2890
2012
-
1
1
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1
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1
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3
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2
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1
1
-
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726202
Vakili
Chromium-induced tropane alkal ...
Atropa belladonna
Plant Physiol. Biochem.
52
98-103
2012
1
-
-
-
-
-
-
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1
-
1
-
1
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2
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2
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2
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2
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1
3
3
1
-
-
724637
Kai
Functional identification of h ...
Anisodus acutangulus
Biotechnol. Lett.
33
1361-1365
2011
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1
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1
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1
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1
1
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713300
Pramod
Biochemical and structural cha ...
Datura metel
Plant Physiol. Biochem.
48
966-970
2010
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1
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2
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1
1
1
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1
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1
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1
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1
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2
1
1
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1
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1
1
-
-
-
700788
Jaber-Vazdekis
Cloning, characterization and ...
Atropa baetica
Plant Physiol. Biochem.
47
20-25
2009
-
-
1
-
-
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-
-
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1
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1
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2
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688836
Cardillo
Expression of Brugmansia candi ...
Brugmansia x candida
Microb. Cell Fact.
7
17
2008
-
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1
-
1
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1
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1
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1
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1
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1
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-
-
-
-
-
-
-
-
700783
Higa
Root tip-dependent, active rib ...
Hyoscyamus albus
Plant Physiol. Biochem.
46
452-460
2008
-
-
1
-
-
-
-
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1
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1
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1
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-
687475
Kai
Molecular cloning and characte ...
Anisodus acutangulus
J. Biochem. Mol. Biol.
40
715-722
2007
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1
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5
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4
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1
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1
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4
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1
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1
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672740
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Tailoring tropane alkaloid acc ...
Hyoscyamus niger
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Exogenous plant H6H but not ba ...
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660331
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Molecular cloning, expression ...
Anisodus tanguticus
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675125
Haekkinen
Enhanced secretion of tropane ...
Hyoscyamus niger
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660281
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Effects of methyl jasmonate an ...
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660278
Palazon
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Alkaloid production in Duboisi ...
Hyoscyamus niger
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439278
Rocha
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Functional expression of tropi ...
Hyoscyamus niger
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439280
Suzuki
An Atropa belladonna hyoscyami ...
Atropa belladonna
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141-152
1999
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5
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439281
Matsuda
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Analysis of active-site residu ...
Hyoscyamus niger
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14
51-57
1997
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5
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439279
Yun
-
Transgenic tobacco plants with ...
Hyoscyamus niger
Biosci. Biotechnol. Biochem.
57
502-503
1993
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439276
Matsuda
Molecular cloning of hyoscyami ...
Hyoscyamus niger
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9460-9464
1991
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439275
Hashimoto
Purification and characterizat ...
Hyoscyamus niger
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1987
6
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31
3
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15
1
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6
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31
2
3
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15
1
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1
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439277
Hashimoto
Hyoscyamine 6beta-hydroxylase, ...
Atropa belladonna, Datura metel, Duboisia leichhardtii, Hyoscyamus albus, Hyoscyamus gyorffi, Hyoscyamus muticus, Hyoscyamus niger, Hyoscyamus pusillus
Plant Physiol.
81
619-625
1986
32
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8
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32
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