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Literature summary for 1.13.99.1 extracted from

  • Deng, F.; Sharma, I.; Dai, Y.; Yang, M.; Kanwar, Y.S.
    Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule (2019), J. Clin. Invest., 129, 5033-5049 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myo-inositol + O2 Homo sapiens
-
 D-glucuronate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HK-2 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myo-inositol + O2
-
 Homo sapiens D-glucuronate + H2O
-
 ?

Subunits

Subunits Comment Organism
? x * 33000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
MIOX
-
 Homo sapiens
Myo-inositol oxygenase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression increases in HK-2 cells after 4 h of cisplatin treatment up

General Information

General Information Comment Organism
physiological function ferroptosis, an integral process in the pathogenesis of cisplatin-induced acute kidney injury, is modulated by the expression profile of the enzyme. Overexpression of the enzyme promotes cisplatin-induced cell death and RSL3-induced ferroptosis in HK-2 cells Homo sapiens