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Literature summary for 1.13.99.1 extracted from

  • Dutta, R.K.; Kondeti, V.K.; Sharma, I.; Chandel, N.S.; Quaggin, S.E.; Kanwar, Y.S.
    Beneficial effects of myo-inositol oxygenase deficiency in cisplatin-induced AKI (2017), J. Am. Soc. Nephrol., 28, 1421-1436. .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in LLC-PK1 cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
myo-inositol + O2 Mus musculus
-
 D-glucuronate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QXN5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myo-inositol + O2
-
 Mus musculus D-glucuronate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MIOX
-
 Mus musculus
Myo-inositol oxygenase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus cisplatin increases the enzyme expression via demethylation of its promoter up

General Information

General Information Comment Organism
physiological function enzyme overexpression exacerbates cisplatin-induced acute kidney injury by accentuating renal tubular cell apoptosis and modulating the expression of inflammatory cytokines Mus musculus