BRENDA - Enzyme Database show
show all sequences of 1.13.99.1

Biochemical studies on inositol. V. Purification and properties of the enzyme that cleaves inositol to D-glucuronic acid

Charalampous, F.C.; J. Biol. Chem. 234, 220-227 (1959)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
cysteine
best activation system: 1 mM Fe(II) and 2 mM cysteine
Rattus norvegicus
quinolinate
1 mM Fe(II) + 4 mM quinolinate activates to 70% of the Fe(II)/cysteine system, Fe(II) alone causes very little activation, quinolinate gives considerable activation in absence of Fe(II), activation by Fe(II) and quinolinate is very temperature dependent
Rattus norvegicus
Inhibitors
Inhibitors
Commentary
Organism
Structure
2-Thenoyltrifluoroacetone
slight
Rattus norvegicus
8-hydroxyquinoline
-
Rattus norvegicus
ADP
slight
Rattus norvegicus
Ag+
-
Rattus norvegicus
AMP
-
Rattus norvegicus
arsenite
-
Rattus norvegicus
ATP
-
Rattus norvegicus
azide
-
Rattus norvegicus
CTP
-
Rattus norvegicus
Cu2+
-
Rattus norvegicus
cyanide
-
Rattus norvegicus
FAD
-
Rattus norvegicus
Furoylthiofluoroacetone
slight
Rattus norvegicus
GTP
-
Rattus norvegicus
Hg2+
-
Rattus norvegicus
hydroxylamine
-
Rattus norvegicus
iodoacetate
-
Rattus norvegicus
menadione
-
Rattus norvegicus
NAD+
-
Rattus norvegicus
NADP+
-
Rattus norvegicus
o-phenanthroline
slight
Rattus norvegicus
p-chloromercuribenzoate
-
Rattus norvegicus
Phenylmercuric nitrate
-
Rattus norvegicus
Quinacrine hydrochloride
slight
Rattus norvegicus
riboflavin phosphate
-
Rattus norvegicus
tetrahydrofolic acid
-
Rattus norvegicus
Uridine diphosphoglucose
-
Rattus norvegicus
UTP
-
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
22.1
-
Inositol
-
Rattus norvegicus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Fe2+
1 mM Fe(II) + 4 mM quinolinate activate to 70% of the Fe(II)/cysteine system, Fe(II) alone causes very little activation, quinolinate gives considerable activation in absence of Fe(II), activation by Fe(II) and quinolinate is very temperature dependent; 1 mM Fe(II) and 2 mM cysteine; best activation system
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
Storage Stability
Storage Stability
Organism
-20°C, extensive loss of activity after 1 or 2 days
Rattus norvegicus
0°C, 12 h, extensive loss of activity
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
highly specific for myo-inositol
6866
Rattus norvegicus
D-glucuronate + H2O
-
-
-
-
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
-
assay at
Rattus norvegicus
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
7.22
-
Inositol
-
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
7.2
-
Rattus norvegicus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6.5
7.4
sharp decrease of activity below pH 6.5 and above pH 7.4
Rattus norvegicus
Cofactor
Cofactor
Commentary
Organism
Structure
flavin
5. 6 mMol per mol of enzyme
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
cysteine
best activation system: 1 mM Fe(II) and 2 mM cysteine
Rattus norvegicus
quinolinate
1 mM Fe(II) + 4 mM quinolinate activates to 70% of the Fe(II)/cysteine system, Fe(II) alone causes very little activation, quinolinate gives considerable activation in absence of Fe(II), activation by Fe(II) and quinolinate is very temperature dependent
Rattus norvegicus
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
flavin
5. 6 mMol per mol of enzyme
Rattus norvegicus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-Thenoyltrifluoroacetone
slight
Rattus norvegicus
8-hydroxyquinoline
-
Rattus norvegicus
ADP
slight
Rattus norvegicus
Ag+
-
Rattus norvegicus
AMP
-
Rattus norvegicus
arsenite
-
Rattus norvegicus
ATP
-
Rattus norvegicus
azide
-
Rattus norvegicus
CTP
-
Rattus norvegicus
Cu2+
-
Rattus norvegicus
cyanide
-
Rattus norvegicus
FAD
-
Rattus norvegicus
Furoylthiofluoroacetone
slight
Rattus norvegicus
GTP
-
Rattus norvegicus
Hg2+
-
Rattus norvegicus
hydroxylamine
-
Rattus norvegicus
iodoacetate
-
Rattus norvegicus
menadione
-
Rattus norvegicus
NAD+
-
Rattus norvegicus
NADP+
-
Rattus norvegicus
o-phenanthroline
slight
Rattus norvegicus
p-chloromercuribenzoate
-
Rattus norvegicus
Phenylmercuric nitrate
-
Rattus norvegicus
Quinacrine hydrochloride
slight
Rattus norvegicus
riboflavin phosphate
-
Rattus norvegicus
tetrahydrofolic acid
-
Rattus norvegicus
Uridine diphosphoglucose
-
Rattus norvegicus
UTP
-
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
22.1
-
Inositol
-
Rattus norvegicus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Fe2+
1 mM Fe(II) + 4 mM quinolinate activate to 70% of the Fe(II)/cysteine system, Fe(II) alone causes very little activation, quinolinate gives considerable activation in absence of Fe(II), activation by Fe(II) and quinolinate is very temperature dependent; 1 mM Fe(II) and 2 mM cysteine; best activation system
Rattus norvegicus
Purification (Commentary) (protein specific)
Commentary
Organism
-
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Rattus norvegicus
-
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, extensive loss of activity after 1 or 2 days
Rattus norvegicus
0°C, 12 h, extensive loss of activity
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
highly specific for myo-inositol
6866
Rattus norvegicus
D-glucuronate + H2O
-
-
-
-
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
35
-
assay at
Rattus norvegicus
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
7.22
-
Inositol
-
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.8
7.2
-
Rattus norvegicus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6.5
7.4
sharp decrease of activity below pH 6.5 and above pH 7.4
Rattus norvegicus
Other publictions for EC 1.13.99.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745009
Shi
Overexpression of the PeaT1 e ...
Oryza sativa
Front. Plant Sci.
8
970
2017
-
-
1
-
-
-
-
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1
-
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2
-
5
-
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1
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2
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1
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1
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2
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1
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2
-
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-
-
-
-
-
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-
1
1
1
1
-
-
744811
Liu
Production of glucaric acid f ...
Komagataella phaffii, Komagataella phaffii GS115, Mus musculus
Enzyme Microb. Technol.
91
8-16
2016
-
-
2
-
1
-
-
-
-
-
-
3
-
6
-
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3
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2
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2
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2
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1
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3
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-
-
3
-
2
-
-
-
2
-
-
-
1
2
2
1
-
-
745343
Tominaga
Transcriptional and translati ...
Homo sapiens, Mus musculus, Mus musculus CD1, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
291
1348-1367
2016
1
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4
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4
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5
-
6
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14
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5
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4
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4
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1
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4
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4
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5
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14
-
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5
-
4
-
-
-
4
-
-
-
8
-
-
8
-
-
745357
Sun
myo-Inositol oxygenase overex ...
Sus scrofa
J. Biol. Chem.
291
5688-5707
2016
-
-
1
-
1
-
-
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1
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1
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1
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4
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1
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1
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1
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1
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1
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1
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1
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4
-
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1
-
1
-
-
-
1
-
-
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1
2
2
1
-
-
745184
Zhan
Disruption of renal tubular m ...
Homo sapiens, Mus musculus
J. Am. Soc. Nephrol.
26
1304-1321
2015
-
2
2
-
-
-
2
-
2
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2
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3
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5
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2
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2
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2
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5
-
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2
-
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-
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2
6
6
2
-
-
746190
Chen
Ectopic expression of a Glyci ...
Arabidopsis thaliana, Glycine soja 07256, Glycine soja
PLoS ONE
10
e0129998
2015
-
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2
-
1
-
-
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3
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6
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4
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3
1
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1
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2
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1
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3
-
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4
-
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3
1
-
-
-
-
-
-
-
1
1
3
3
1
-
-
728381
Siddique
Myo-inositol oxygenase is impo ...
Arabidopsis thaliana
New Phytol.
201
476-85
2014
-
-
-
-
-
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-
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5
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1
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1
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1
2
2
1
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744739
Gaut
Development of an immunoassay ...
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Clin. Chem.
60
747-757
2014
-
1
1
-
-
-
-
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3
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7
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8
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3
1
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1
1
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3
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8
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3
1
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-
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2
2
-
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-
745898
Siddique
Myo-inositol oxygenase is imp ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
New Phytol.
201
476-485
2014
-
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1
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1
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8
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12
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4
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8
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4
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4
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8
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14
-
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8
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-
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-
-
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1
2
8
4
-
-
727646
Senthilraja
-
Computational screening and do ...
Homo sapiens
Int. J. Pharm. Sci. Rev. Res.
20
158-161
2013
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6
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1
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727579
Alford
myo-Inositol oxygenase is requ ...
Arabidopsis thaliana
Front. Plant Sci.
3
69
2012
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2
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2
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1
1
1
1
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727881
Nayak
Transcriptional and post-trans ...
Mus musculus
J. Biol. Chem.
286
27594-27611
2011
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1
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3
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1
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1
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1
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1
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2
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2
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712593
Yang
Polymorphisms of myo-inositol ...
Homo sapiens
J. Diabetes Complicat.
24
404-408
2010
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1
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2
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695783
Moon
Production of glucaric acid fr ...
Mus musculus
Appl. Environ. Microbiol.
75
589-595
2009
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1
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5
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9
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1
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9
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1
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1
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1
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1
1
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-
697532
Bollinger
myo-Inositol oxygenase: a radi ...
Mammalia, Mus musculus
Dalton Trans.
2009
905-914
2009
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2
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3
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1
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2
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2
2
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-
697793
Lu
Increased expression of myo-in ...
Rattus norvegicus
Exp. Clin. Endocrinol. Diabetes
117
257-265
2009
1
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1
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1
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1
1
1
1
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-
700488
Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
184
457-472
2009
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1
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5
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9
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2
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4
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8
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