Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-carotene + O2 | Mus musculus | - |
2 all-trans-retinal | - |
? | |
beta-carotene + O2 | Mus musculus C57BL/6 | - |
2 all-trans-retinal | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JJS6 | - |
- |
Mus musculus C57BL/6 | Q9JJS6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Mus musculus | - |
brain | adult and embryonic, very low Bco1 expression level | Mus musculus | - |
embryo | - |
Mus musculus | - |
eye | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
liver | adult and embryonic, high Bco1 expression level | Mus musculus | - |
lung | - |
Mus musculus | - |
mammary gland | - |
Mus musculus | - |
additional information | retinoid levels in the developing liver and brain at mid-gestation, overview. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type | Mus musculus | - |
pancreas | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-carotene + O2 | - |
Mus musculus | 2 all-trans-retinal | - |
? | |
beta-carotene + O2 | - |
Mus musculus C57BL/6 | 2 all-trans-retinal | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCO1 | - |
Mus musculus |
beta-carotene 15,15' oxygenase | - |
Mus musculus |
beta-carotene 15,15'-oxygenase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deficiency of BCO1 in the liver does not significantly affect retinol or retinyl ester concentrations compared to the wild-type group, even though retinyl ester levels tend to be lower in the absence of BCO1. BCO1-/- and wild-type female mice reveal a statistically significant decrease in retinol content in the heart, pancreas, spleen, eye and adipose tissue of the knockout females. Retinol concentrations are greater in the lungs of the BCO1-/- females compared to wild-type | Mus musculus |