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Information on EC - beta-carotene 15,15'-dioxygenase

for references in articles please use BRENDA:EC1.13.11.63
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IUBMB Comments
Requires Fe2+. The enzyme cleaves beta-carotene symmetrically, producing two molecules of all-trans-retinal. Both atoms of the oxygen molecule are incorporated into the products . The enzyme can also process beta-cryptoxanthin, 8'-apo-beta-carotenal, 4'-apo-beta-carotenal, alpha-carotene and gamma-carotene in decreasing order. The presence of at least one unsubstituted beta-ionone ring in a substrate greater than C(30) is mandatory . A prokaryotic enzyme has been reported from the uncultured marine bacterium 66A03, where it is involved in the proteorhodopsin system, which uses retinal as its chromophore [6,7].
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
BC-15,15'-oxygenase, BCM, BCMO, Bcmo1, Bcmo2, BCO, BCO1, BCO2, Bcox, beta,beta-carotene 15,15'-mono-oxygenase 1, more
beta-carotene + O2 = 2 all-trans retinal
show the reaction diagram
beta-carotene + O2 = 2 all-trans-retinal
show the reaction diagram