Activating Compound | Comment | Organism | Structure |
---|---|---|---|
FLAP | the 5-LOX activating protein (FLAP) assists the translocation of 5-LOX from plasma membranes to nucleus upon cell stimulation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | Ca2+-mediated translocation from plasma membranes to nucleus upon cell stimulation, the translocation of 5-LOX is assisted by a 5-LOX activating protein (FLAP) | Homo sapiens | - |
- |
nuclear membrane | - |
Homo sapiens | 31965 | - |
plasma membrane | iron removal is able to affect the membrane binding properties of the enzyme, molecular dynamics simulations, overview | Homo sapiens | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a non-heme iron-containing enzyme. LOX catalytic activity depends on the presence of iron in the active site. Iron removal is able to affect the membrane binding properties of the enzyme, molecular dynamics simulations, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme catalyzes the dioxygenation of polyunsaturated fatty acids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09917 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme catalyzes the dioxygenation of polyunsaturated fatty acids | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | structure modeling, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5-LOX | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | molecular dynamics simulations the conformational changes induced by iron removal in 5-LOX, overview. The degree of enzyme flexibility is related to the presence of iron into the active site that is able to stabilize the protein increasing its rigidity, structure modeling based on the crystal structure at 2.4 A resolution, overview | Homo sapiens |
physiological function | leukotrienes biosynthesis is initiated by the action of 5-LOX at the level of nuclear membrane and the mechanism of enzyme-membrane interaction is thought to involve structural flexibility and conformational changes at the level of the protein tertiary structure. The conformational change between the apo- and holo-5-LOX might contribute in vivo to the 5-LOX trafficking among different compartments of the cell, thus leading to a modulation of its signaling | Homo sapiens |