Application | Comment | Organism |
---|---|---|
medicine | fosfomycin is a clinically utilized antibiotic of low toxicity, blocking bacterial cell wall biosynthesis by acting as an analogue of phosphoenolpyruvate | Streptomyces fradiae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2 | Streptomyces fradiae | - |
cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+ | i.e. fosfomycin | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces fradiae | D2SNF6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-2-hydroxybutylphosphonic acid + 2 NADH + O2 | - |
Streptomyces fradiae | cis-(1R,2S)-epoxybutylphosphonic acid + 2 H2O + 2 NAD+ | - |
? | |
(S)-2-hydroxypropylphosphonic acid + 2 NADH + O2 | - |
Streptomyces fradiae | cis-(1R,2S)-epoxypropylphosphonic acid + 2 H2O + 2 NAD+ | i.e. fosfomycin | ? | |
additional information | no activity with 2-hydroxyethyl phosphonic acid | Streptomyces fradiae | ? | - |
? |