Inhibitors | Comment | Organism | Structure |
---|---|---|---|
16beta-m-pyridylmethylamidomethyl-2-methoxyoestrone | IC50: 0.00029 mM | Homo sapiens | |
2-methoxyoestrone | IC50: 0.0024 mM | Homo sapiens | |
equilin | IC50: 0.0017 mM | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | Homo sapiens | 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours | estradiol + NAD(P)+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-47D cell | 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estrone + NAD(P)H + H+ | 17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours | Homo sapiens | estradiol + NAD(P)+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17beta-HSD1 | - |
Homo sapiens |
17beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00029 | - |
IC50: 0.00029 mM | Homo sapiens | 16beta-m-pyridylmethylamidomethyl-2-methoxyoestrone | |
0.0017 | - |
IC50: 0.0017 mM | Homo sapiens | equilin | |
0.0024 | - |
IC50: 0.0024 mM | Homo sapiens | 2-methoxyoestrone |