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Information on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

for references in articles please use BRENDA:EC1.1.1.62

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IUBMB Comments

The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.270, 3β-hydroxysteroid 3-dehydrogenase . The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, 20α-hydroxysteroid dehydrogenase, it is Si-specific with respect to NAD(P)+.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
hsd17b4, hsd17b2, 20 alpha-hydroxysteroid dehydrogenase, 17betahsd, 17-hsd, akr1c4, hsd17b12, 17beta-hsd type 1, 17hsd1, 17betahsd1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
estradiol biosynthesis I (via estrone)