Crystallization (Comment) | Organism |
---|---|
crystallized with bound inhibitor carbenoxolone, asymmetric tetramer, Tyr152, Lys156 and Ser139 are conserved as the catalytic triade | Streptomyces exfoliatus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbenoxolone | - |
Streptomyces exfoliatus | |
glycyrrhizic acid | - |
Streptomyces exfoliatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H | Streptomyces exfoliatus | enzyme belongs to the group of short-chain dehydrogenases | ? | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces exfoliatus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H | enzyme belongs to the group of short-chain dehydrogenases | Streptomyces exfoliatus | ? | - |
r |
Subunits | Comment | Organism |
---|---|---|
More | tetrameric, monomers with beta-alpha-beta-motif | Streptomyces exfoliatus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Streptomyces exfoliatus | |
NADH | - |
Streptomyces exfoliatus |