Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
11-deoxycortisol + NADH + H+
? + NAD+
11alpha-hemisuccinyloxyprogesterone + NADH
?
-
Substrates: -
Products: -
?
17-hydroxy-3,11,20-trioxo-4-pregnen-21-oate + NADH
17,20-dihydroxy-3,11-dioxo-4-pregnen-21-oate + NAD+
-
Substrates: -
Products: -
?
17-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20-dihydroxy-4-pregnen-3-one-21-oate + NAD+
-
Substrates: -
Products: -
?
17-hydroxyprogesterone + NADH
?
-
Substrates: -
Products: -
?
17-hydroxyprogesterone + NADPH
17,20-beta-dihydroxy-4-pregnene-3-one
-
Substrates: -
Products: -
?
17alpha,20beta-dihydroxypregn-4-ene-3-one + NADP+
17alpha-hydroxypregn-4-en-3,20-dione + NADPH
-
Substrates: -
Products: -
?
17alpha-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20alpha-dihydroxy-4-pregnen-3-one-21-oate + NAD+
17alpha-hydroxypregnenolone + NADPH
3beta,17alpha,20beta-trihydroxypregn-5-ene + NADP+
-
Substrates: i.e. 3beta,17alpha-dihydroxypregn-5-ene-20-one
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
17beta-estradiol + NAD+
estrone + NADH + H+
17beta-hydroxyandrostan-2-one + NADH + H+
?
-
Substrates: -
Products: -
r
17beta-[(1S)-1-hydroxy-2-propynyl]-androst-4-ene-3-one + NAD+
17beta-[1-oxo-2-propynyl]-androst-4-ene-3-one + NADH
-
Substrates: -
Products: -
?
20alpha-hydroxyprogesterone + NAD+
? + NADH
20beta-hydroxycortisone + NADH + H+
cortisone + NADH + H+
20beta-hydroxypregn-4-ene-3-one + NADP+
pregn-4-ene-3,20-dione + NADPH
-
Substrates: -
Products: -
?
20beta-hydroxyprogesterone + NAD+
? + NADH
21-acetoxyprogesterone + NADH
?
-
Substrates: -
Products: -
?
21-hemisuccinyloxyprogesterone + NADH
?
-
Substrates: -
Products: -
?
3,20-dioxo-4-pregnen-21-oic acid + NADH
20beta-hydroxy-3-oxo-4-pregnen-21-oic acid + NAD+
-
Substrates: -
Products: -
?
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H
?
3beta,17alpha,20alpha-trihydroxypregn-5-ene + NADP+
3beta,17alpha-dihydroxypregn-5-en-20-one + NADPH
-
Substrates: -
Products: -
?
3beta,20alpha-dihydroxypregn-5-ene + NADP+
3beta-hydroxypregn-5-en-20-one + NADPH
-
Substrates: -
Products: -
?
4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide + NADPH
hydroxyhexamide + NADP+
-
Substrates: male-specific and androgen-dependent activity, competitive to progesterone, cortisone, cortisol and 17alpha-hydroxyprogestrone consumption
Products: -
?
4-nitrobenzaldehyde + NADPH
?
-
Substrates: -
Products: -
?
4-pregnen-11beta,21-diol-3,20-dione + NADPH
4-pregnen-11beta,20alpha,21-triol-3-one + NADP+
-
Substrates: -
Products: -
?
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
5alpha-androstan-3alpha-ol-17-one + alpha-NAD+
5alpha-dihydrotestosterone + alpha-NADH + H+
-
Substrates: -
Products: -
r
5alpha-androstan-3alpha-ol-17-one + beta-NAD+
5alpha-dihydrotestosterone + beta-NADH + H+
-
Substrates: -
Products: -
r
5alpha-androstane-3,17-dione + NADPH
?
-
Substrates: -
Products: -
?
5alpha-dihydrotestosterone + alpha-NADH + H+
5alpha-androstan-3alpha-ol-17-one + alpha-NAD+
-
Substrates: -
Products: -
r
5alpha-dihydrotestosterone + alpha-NADPH + H+
5alpha-androstan-3alpha-ol-17-one + alpha-NADP+
-
Substrates: -
Products: -
r
5alpha-dihydrotestosterone + beta-NADH + H+
5alpha-androstan-3alpha-ol-17-one + beta-NAD+
-
Substrates: -
Products: -
r
5alpha-dihydrotestosterone + NADP+
5alpha-androstane-3,17-dione + NADPH + H+
-
Substrates: -
Products: -
?
5alpha-dihydrotestosterone + NADPH
5alpha-androstan-3alpha,17beta-diol + NAD+
Substrates: -
Products: -
?
5alpha-dihydrotestosterone + NADPH + H+
5alpha-androstan-3alpha,17beta-diol + NADP+
Substrates: 14.4% of the activity with p-nitrobenzaldehyde
Products: -
?
5alpha-pregnane-3,20-dione + NADH
?
-
Substrates: -
Products: -
?
5alpha-pregnane-3,20-dione + NADPH
?
-
Substrates: -
Products: -
?
5beta-androstan-17beta-ol-3-one + NAD(P)H
?
-
Substrates: i.e. 5beta-dihydrotestosterone
Products: -
?
5beta-dihydrotestosterone + NADPH
5beta-androstan-3alpha,17beta-diol + NADP+
Substrates: 9.2% of the activity with p-nitrobenzaldehyde
Products: -
?
6beta-(bromoacetoxy)-progesterone + NADH
?
-
Substrates: -
Products: -
?
6beta-[bromoacetoxy]-progesterone + NAD+
?
-
Substrates: -
Products: -
r
9,10-phenanthrenequinone + NADPH
?
-
Substrates: -
Products: -
?
androsterone + NAD+
? + NADH
camphorquinone + NADPH + H+
camphorquinol + NADP+
-
Substrates: -
Products: -
?
corticosterone + NADH + H+
? + NAD+
cortisone + NAD(P)H
17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
cortisone + NADH + H+
20beta-hydroxycortisone + NAD+
cortisone + NADPH + H+
20beta-hydroxycortisone + NADP+
cyclohexanone + NADPH
cyclohexanol + NADP+
-
Substrates: -
Products: -
?
deoxycorticosterone + NADPH
20,21-dihydroxypregn-4-ene-3-one + NADP+
deoxycortisol + NADPH
?
-
Substrates: -
Products: -
?
epiandrosterone + NAD+
? + NADH
hydrindantin + NADPH
?
-
Substrates: -
Products: -
?
menadione + NADPH
?
Substrates: 75% of the activity with p-nitrobenzaldehyde
Products: -
?
methylglyoxal + NADPH
?
-
Substrates: -
Products: -
?
p-nitrobenzaldehyde + NADPH
p-nitrobenzyl alcohol + NADP+
Substrates: -
Products: -
?
phenylglyoxal + NADPH
?
-
Substrates: -
Products: -
?
pregnenolone + NADPH
3beta,20beta-Dihydroxypregn-5-ene + NADP+
-
Substrates: i.e. 3-hydroxypregn-5-en-20-one
Products: -
?
progesterone + NAD(P)H
20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
progesterone + NADH
20beta-hydroxy-pregn-4-ene-3-one + NAD+
Substrates: 22% of the activity with androsterone
Products: -
?
progesterone + NADP+
20beta-hydroxy-pregn-4-ene-3-one + NADPH + H+
-
Substrates: -
Products: -
?
progesterone + NADPH
20beta-hydroxy-pregn-4-ene-3-one + NADP+
tetrahydrocortisol + NADH + H+
? + NAD+
additional information
?
-
11-deoxycortisol + NADH + H+
? + NAD+
-
Substrates: i.e. 4-pregnen-17,21-diol-3,20-dione, 49.8% of the activity compared to cortisone
Products: -
?
11-deoxycortisol + NADH + H+
? + NAD+
-
Substrates: i.e. 4-pregnen-17,21-diol-3,20-dione, 49.8% of the activity compared to cortisone
Products: -
?
17alpha-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20alpha-dihydroxy-4-pregnen-3-one-21-oate + NAD+
-
Substrates: -
Products: -
?
17alpha-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20alpha-dihydroxy-4-pregnen-3-one-21-oate + NAD+
-
Substrates: -
Products: -
?
17alpha-hydroxy-3,20-dioxo-4-pregnen-21-oate + NADH
17,20alpha-dihydroxy-4-pregnen-3-one-21-oate + NAD+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: -
Products: maturation-inducing hormone of oocytes
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: 4.3% of the activity with p-nitrobenzaldehyde
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: -
Products: maturation-inducing hormone of oocytes
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: -
Products: maturation-inducing hormone of oocytes
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
Substrates: 4.3% of the activity with p-nitrobenzaldehyde
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: 20beta-hydroxysteroid dehydrogenase activity is reduced in diabetic rats
Products: -
r
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-4-pregnene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: 17alpha-hydroxyprogesterone reduction in non-flagellated germ cells and in spermatozoa
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: enzyme wild type A and B, mutants of enzyme type A and B
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
r
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
17alpha-hydroxyprogesterone + NADPH + H+
17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
17beta-estradiol + NAD+
estrone + NADH + H+
Substrates: 4% of the activity with androsterone
Products: -
?
17beta-estradiol + NAD+
estrone + NADH + H+
Substrates: 4% of the activity with androsterone
Products: -
?
20alpha-hydroxyprogesterone + NAD+
? + NADH
Substrates: 2% of the activity with androsterone
Products: -
?
20alpha-hydroxyprogesterone + NAD+
? + NADH
Substrates: 2% of the activity with androsterone
Products: -
?
20beta-hydroxycortisone + NADH + H+
cortisone + NADH + H+
-
Substrates: under in vitro conditions, the enzyme catalyzes reductive reaction far more readily than oxidative reaction
Products: -
r
20beta-hydroxycortisone + NADH + H+
cortisone + NADH + H+
-
Substrates: under in vitro conditions, the enzyme catalyzes reductive reaction far more readily than oxidative reaction
Products: -
r
20beta-hydroxyprogesterone + NAD+
? + NADH
Substrates: 69% of the activity with androsterone
Products: -
?
20beta-hydroxyprogesterone + NAD+
? + NADH
Substrates: 69% of the activity with androsterone
Products: -
?
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H
?
-
Substrates: enzyme belongs to the group of short-chain dehydrogenases
Products: -
?
3alpha,20beta-hydroxysteroid androstanes or pregnane derivatives + NAD(P)H
?
-
Substrates: enzyme belongs to the group of short-chain dehydrogenases
Products: -
r
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
Substrates: i.e. 5alpha-dihydrotestosterone
Products: -
?
5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+
5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
Substrates: i.e. 5alpha-dihydrotestosterone
Products: ratio 4:3
?
androsterone + NAD+
? + NADH
Substrates: -
Products: -
?
androsterone + NAD+
? + NADH
Substrates: -
Products: -
?
corticosterone + NADH + H+
? + NAD+
-
Substrates: i.e. 4-pregnen-11beta,21-diol-3,20-dione, 39.8% of the activity compared to cortisone
Products: -
?
corticosterone + NADH + H+
? + NAD+
-
Substrates: i.e. 4-pregnen-11beta,21-diol-3,20-dione, 39.8% of the activity compared to cortisone
Products: -
?
cortisone + NAD(P)H
17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
-
Substrates: -
Products: -
?
cortisone + NAD(P)H
17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
-
Substrates: -
Products: -
?
cortisone + NAD(P)H
17alpha,20beta,21-trihydroxy-pregn-4-ene-3,11-dione + NAD(P)+
-
Substrates: i.e. 17beta,21-dihydroxy-pregn-4-ene-3,11,20-trione
Products: -
?
cortisone + NADH + H+
20beta-hydroxycortisone + NAD+
-
Substrates: the equilibrium for the recombinant enzyme clearly favors the reductive direction. Cortisol is the preferred substrate, as it is more rapidly converted to 20beta-dihydrocortisol relative to other structurally similar steroids tested
Products: -
r
cortisone + NADH + H+
20beta-hydroxycortisone + NAD+
-
Substrates: the equilibrium for the recombinant enzyme clearly favors the reductive direction. Cortisol is the preferred substrate, as it is more rapidly converted to 20beta-dihydrocortisol relative to other structurally similar steroids tested
Products: -
r
cortisone + NADPH + H+
20beta-hydroxycortisone + NADP+
-
Substrates: -
Products: i.e. 4-pregnen-17alpha,20beta,21-triol-3,11-dione
?
cortisone + NADPH + H+
20beta-hydroxycortisone + NADP+
-
Substrates: no activity with NAD+
Products: -
?
deoxycorticosterone + NADPH
20,21-dihydroxypregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
deoxycorticosterone + NADPH
20,21-dihydroxypregn-4-ene-3-one + NADP+
-
Substrates: i.e. 21-hydroxypregn-4-ene-3,20-dione, 21-hydroxyprogesterone
Products: -
?
epiandrosterone + NAD+
? + NADH
Substrates: 3% of the activity with androsterone
Products: -
?
epiandrosterone + NAD+
? + NADH
Substrates: 3% of the activity with androsterone
Products: -
?
progesterone + NAD(P)H
20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
Substrates: -
Products: -
?
progesterone + NAD(P)H
20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
Substrates: -
Products: -
r
progesterone + NAD(P)H
20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
Substrates: -
Products: -
?
progesterone + NAD(P)H
20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
Substrates: -
Products: -
?
progesterone + NADPH
20beta-hydroxy-pregn-4-ene-3-one + NADP+
Substrates: 2.5% of the activity with p-nitrobenzaldehyde
Products: -
?
progesterone + NADPH
20beta-hydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
progesterone + NADPH
20beta-hydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: 20beta-hydroxysteroid dehydrogenase activity is reduced in diabetic rats
Products: -
r
progesterone + NADPH
20beta-hydroxy-pregn-4-ene-3-one + NADP+
-
Substrates: -
Products: -
?
tetrahydrocortisol + NADH + H+
? + NAD+
-
Substrates: i.e. 5beta-pregnan-3alpha,11beta,17,21-tetrol-20-one, 49.2% of the activity compared to cortisone
Products: -
?
tetrahydrocortisol + NADH + H+
? + NAD+
-
Substrates: i.e. 5beta-pregnan-3alpha,11beta,17,21-tetrol-20-one, 49.2% of the activity compared to cortisone
Products: -
?
additional information
?
-
-
Substrates: catalyzes the oxidoreduction of a variety of steroid substrates, including the steroid antibiotic fusidic acid, catalyzes the interconversion of hydroxy and oxo groups at position 3 of the steroid ring structure, enzyme is capable of catalyzing the carbonyl reduction of non-steroidal xenobiotic carbonyl compounds, contributes to the bioremediation of natural and synthetic toxicants, plays a central role in steroid metabolism
Products: -
?
additional information
?
-
-
Substrates: constitutive enzyme
Products: -
?
additional information
?
-
Substrates: catalyzes the NADPH reduction of carbonyl compounds and steroids, steroidogenic enzyme, key enzyme for the production of maturation-induced steroid
Products: -
?
additional information
?
-
Substrates: the enzyme plays an important role in the meiotic maturation of tilapia gametes
Products: -
?
additional information
?
-
-
Substrates: the enzyme plays an important role in the meiotic maturation of tilapia gametes
Products: -
?
additional information
?
-
-
Substrates: enzyme cannot catalyze the reduction of 11-hydroxy- or 11-oxo-C21-steroids, i.e. cortisol, corticosterone, cortisone
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
11beta-hydroxysteroid dehydrogenase deficiency
11beta-hydroxysteroid dehydrogenase type 1 deficiency ('apparent cortisone reductase deficiency') in a 6-year-old boy.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
11?-hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
11{beta}-Hydroxysteroid Dehydrogenase Type 1: A Tissue-Specific Regulator of Glucocorticoid Response.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
A follow-up history of young man with apparent cortisone reductase deficiency (ACRD) - several years after diagnosis.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Alterations of Cortisol Metabolism in Human Disorders.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Apparent cortisone reductase deficiency: a functional defect in 11beta-hydroxysteroid dehydrogenase type 1.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Apparent cortisone reductase deficiency: a rare cause of hyperandrogenemia and hypercortisolism.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Apparent cortisone reductase deficiency: a unique form of hypercortisolism.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Association Study of CYP17 and HSD11B1 in Polycystic Ovary Syndrome Utilizing Comprehensive Gene Coverage.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Cortisone-reductase deficiency associated with heterozygous mutations in 11{beta}-hydroxysteroid dehydrogenase type 1.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Defects in the HSD11 gene encoding 11 beta-hydroxysteroid dehydrogenase are not found in patients with apparent mineralocorticoid excess or 11-oxoreductase deficiency.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Estimation of reference curves for the urinary steroid metabolome in the first year of life in healthy children: Tracing the complexity of human postnatal steroidogenesis.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Hexose-6-phosphate dehydrogenase confers oxo-reductase activity upon 11 beta-hydroxysteroid dehydrogenase type 1.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Novel H6PDH mutations in two girls with premature adrenarche: 'apparent' and 'true' CRD can be differentiated by urinary steroid profiling.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Novel insight into etiology, diagnosis and management of primary adrenal insufficiency.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Physiological roles of 11 beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Premature adrenarche: novel lessons from early onset androgen excess.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome.
3alpha(or 20beta)-hydroxysteroid dehydrogenase deficiency
[11beta-hydroxysteroide dehydrogenases. Recent advances]
Cushing Syndrome
Apparent cortisone reductase deficiency: a rare cause of hyperandrogenemia and hypercortisolism.
Cushing Syndrome
Apparent cortisone reductase deficiency: a unique form of hypercortisolism.
Hyperandrogenism
Alterations of Cortisol Metabolism in Human Disorders.
Hyperandrogenism
Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome.
Hyperandrogenism
Hexose 6-phosphate dehydrogenase (H6PD) and corticosteroid metabolism.
Hyperandrogenism
Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome.
Hypertension
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
Insulin Resistance
Cortisol metabolism and the role of 11beta-hydroxysteroid dehydrogenase.
nadph-hemoprotein reductase deficiency
Estimation of reference curves for the urinary steroid metabolome in the first year of life in healthy children: Tracing the complexity of human postnatal steroidogenesis.
nadph-hemoprotein reductase deficiency
Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS).
nadph-hemoprotein reductase deficiency
Novel insight into etiology, diagnosis and management of primary adrenal insufficiency.
nadph-hemoprotein reductase deficiency
Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis.
Polycystic Ovary Syndrome
A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome.
Polycystic Ovary Syndrome
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency.
Polycystic Ovary Syndrome
Mutations of the hexose-6-phosphate dehydrogenase gene rarely cause hyperandrogenemic polycystic ovary syndrome.
Polycystic Ovary Syndrome
Variants implicated in cortisone reductase deficiency do not contribute to susceptibility to common forms of polycystic ovary syndrome.
steroid sulfotransferase deficiency
Premature adrenarche: novel lessons from early onset androgen excess.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Tyrakowska, B.; Verhaert, R.M.D.; Hilhorst, R.; Veeger, C.
Enzyme kinetics in reversed micelles. 3. Behaviour of 20beta-hydroxysteroid dehydrogenase
Eur. J. Biochem.
187
81-88
1990
Streptomyces exfoliatus
brenda
Nakajin, S.; Ohno, S.; Shinoda, M.
20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: purification and some properties
J. Biochem.
104
565-569
1988
Sus scrofa
brenda
Carrea, G.; Pasta, P.
Properties of immobilized subunits of 20beta-hydroxysteroid dehydrogenase
Methods Enzymol.
135
475-483
1987
Streptomyces exfoliatus
brenda
Vecchio, G.; Pasta, P.; Mazzola, G.; Carrea, G.
Multiparameter study of denaturation of 20beta-hydroxysteroid dehydrogenase by urea in the presence of stabilizing agents
Biochim. Biophys. Acta
914
122-126
1987
Streptomyces exfoliatus
brenda
Carrea, G.; Cremonesi, P.
Enzyme-catalyzed steroid transformations in water-organic solvent two-phase systems
Methods Enzymol.
136
150-157
1987
Streptomyces exfoliatus
-
brenda
Carrea, G.; Pasta, P.; Vecchio, G.
Effect of the lyotropic series of anions on denaturation and renaturation of 20beta-hydroxysteroid dehydrogenase
Biochim. Biophys. Acta
784
16-23
1984
Streptomyces exfoliatus
brenda
Strickler, R.C.; Covey, D.F.; Tobias, B.
Study of 3alpha, 20beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site
Biochemistry
19
4950-4954
1980
Streptomyces exfoliatus
brenda
Sweet, F.; Samant, B.R.
Bifunctional enzyme activity at the same active site: study of 3alpha and 20beta activity by affinity alkylation of 3alpha, 20beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids
Biochemistry
19
978-986
1980
Streptomyces exfoliatus
brenda
Monder, C.
Reduction of steroidal 20-oxo-21-oic acids to steroidal 20-beta-hydroxy-21-oic acids by 20beta-hydroxysteroid dehydrogenase
J. Steroid Biochem.
9
1229-1231
1978
Streptomyces exfoliatus
brenda
Sweet, F.; Patrick, T.B.; Judd, M.
Substrate characteristics of progesterone-albumin conjugates with 20beta-hydroxysteroid dehydrogenase
Biochem. Biophys. Res. Commun.
83
187-194
1978
Streptomyces exfoliatus
brenda
Edwards, C.A.F.; Orr, J.C.
Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans
Biochemistry
17
4370-4376
1978
Streptomyces exfoliatus
brenda
Szymanski, E.S.; Furfine, C.S.
20beta-Hydroxysteroid oxidoreductase. Kinetics and binding of corticosteroids and corticosteroid-21-aldehydes
J. Biol. Chem.
252
205-211
1977
Streptomyces exfoliatus
brenda
Hubner, H.J.; Sahrholz, F.G.
20beta-hydroxy-steroid-dehydrogenase II. Darstellung und Kristallisation
Biochem. Z.
333
95-105
1960
Streptomyces exfoliatus
-
brenda
Lynn, W.S.; Brown, R.H.
The conversion of progesterone to androgens by testes
J. Biol. Chem.
232
1015-1030
1958
Cavia porcellus
brenda
Ohno, S.; Nakajin, S.; Shinoda, M.
20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: 3alpha/beta-hydroxysteroid dehydrogenase activities catalyzed by highly purified enzyme
J. Steroid Biochem. Mol. Biol.
38
787-794
1991
Sus scrofa
brenda
Ohno, S.; Nakajin, S.; Shinoda, M.
20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: reverse catalytic (oxidation) reaction
Chem. Pharm. Bull.
39
972-975
1991
Sus scrofa
brenda
Blomquist, C.H.
The molecular weight and substrate specificity of 20beta-hydroxysteroid dehydrogenase from Streptomyces hydrogenans
Arch. Biochem. Biophys.
159
590-595
1973
Streptomyces exfoliatus
-
brenda
Krook, M.; Prozorovski, V.; Atrian, S.; Gonzalez-Duarte, R.; Jrnvall, H.
Short-chain dehydrogenases. Proteolysis and chemical modification of prokaryotic 3alpha/20beta-hydroxysteroid, insect alcohol and human 15-hydroxyprostaglandin dehydrogenase
Eur. J. Biochem.
209
233-239
1992
Streptomyces exfoliatus
brenda
Takada, H.; Otagiri, M.; Imamura, Y.
20beta-Hydroxysteroid dehydrogenase catalyzes ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of adult male rats
J. Pharmacol. Exp. Ther.
287
504-507
1998
Rattus norvegicus
brenda
Takada, H.; Uchida, A.; Kamizono, R.; Otagiri, M.; Imamura, Y.
Further studies on 20beta-hydroxysteroid dehydrogenase with carbonyl reductase-like activity present in liver microsomes of male rats
Life Sci.
67
2075-2082
2000
Rattus norvegicus
brenda
Ohno, S.; Nakajin, S.; Shinoda, M.
Ontogeny of testicular steroid dehydrogenase enzymes in pig (3alpha/beta-, 20alpha- and 20beta-): evidence for two forms of 3alpha/beta-hydroxysteroid dehydrogenase
J. Steroid Biochem. Mol. Biol.
42
17-21
1992
Sus scrofa
brenda
Adachi, S.; Nagahama, Y.
Involvement of pH in the enhancement of 20beta-hydroxysteroid dehydrogenase activity in isolated granulosa cell layers from ovarian follicles of salmonid fishes
Biomed. Res.
11
327-335
1990
Oncorhynchus mykiss, Oncorhynchus masou rhodurus
-
brenda
Tanaka, M.; Ohno, S.; Adachi, S.; Nakajin, S.; Shinoda, M.; Nagahama, Y.
Pig testicular 20beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity
J. Biol. Chem.
267
13451-13455
1992
Sus scrofa
brenda
Guan, G.; Todo, T.; Tanaka, M.; Young, G.; Nagahama, Y.
Isoleucine-15 of rainbow trout carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase is critical for coenzyme (NADPH) binding
Proc. Natl. Acad. Sci. USA
97
3079-3083
2000
Oncorhynchus mykiss
brenda
Vizziano, D.; Fostier, A.; Le Gac, F.; Loir, M.
20beta-Hydroxysteroid dehydrogenase activity in nonflagellated germ cells of rainbow trout testis
Biol. Reprod.
54
1-7
1996
Oncorhynchus mykiss
brenda
Ghosh, D.; Erman, M.; Wawrzak, Z.; Duax, W.L.; Pangborn, W.
Mechanism of inhibition of 3alpha, 20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor
Curr. Biol.
2
973-980
1994
Streptomyces exfoliatus
brenda
Ghosh, D.; Wawrzak, Z.; Weeks, C.M.; Duax, W.L.; Erman, M.
The refined three-dimensional structure of 3alpha,20beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases
Structure
2
629-640
1994
Streptomyces exfoliatus
brenda
Kazeto, Y.; Adachi, S.; Yamauchi, K.
20beta-hydroxysteroid dehydrogenase of the japanes eel ovary: its cellular localization and changes in the enzymatic acitvity during sexual maturation
Gen. Comp. Endocrinol.
122
109-115
2001
Anguilla japonica
brenda
Senthilkumaran, B.; Sudhakumari, C.C.; Chang, X.T.; Kobayashi, T.; Oba, Y.; Guan, G.; Yoshiura, Y.; Yoshikuni, M.; Nagahama, Y.
Ovarian carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase shows distinct surge in messenger RNA expression during natural and gonadotropin-induced meiotic maturation in Nile tilapia
Biol. Reprod.
67
1080-1086
2002
Oreochromis niloticus (Q8UVJ2), Oreochromis niloticus
brenda
Wang, Y.; Ge, W.
Cloning of zebrafish ovarian carbonyl reductase-like 20 beta-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression
Gen. Comp. Endocrinol.
127
209-216
2002
Danio rerio
brenda
Yang, J.K.; Park, M.S.; Waldo, G.S.; Suh, S.W.
Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis
Proc. Natl. Acad. Sci. USA
100
455-460
2003
Mycobacterium tuberculosis (P9WGT1), Mycobacterium tuberculosis H37Rv (P9WGT1)
brenda
Sreenivasulu, G.; Swapna, I.; Rasheeda, M.K.; Ijiri, S.; Adachi, S.; Thangaraj, K.; Senthilkumaran, B.
Expression of 20beta-hydroxysteroid dehydrogenase and P450 17alpha-hydroxylase/c17-20 lyase during hCG-induced in vitro oocyte maturation in snake head murrel Channa striatus
Fish Physiol. Biochem.
31
227-230
2006
Channa striata, Gallus gallus
brenda
Nakamura, I.; Evans, J.C.; Kusakabe, M.; Nagahama, Y.; Young, G.
Changes in steroidogenic enzyme and steroidogenic acute regulatory protein messenger RNAs in ovarian follicles during ovarian development of rainbow trout (Oncorhynchus mykiss)
Gen. Comp. Endocrinol.
144
224-231
2005
Oncorhynchus mykiss
brenda
Albertsson, E.; Kling, P.; Gunnarsson, L.; Larsson, D.G.; Foerlin, L.
Proteomic analyses indicate induction of hepatic carbonyl reductase/20beta-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent
Ecotoxicol. Environ. Safety
68
33-39
2007
Oncorhynchus mykiss (Q9PT36), Oncorhynchus mykiss
brenda
Hoffmann, F.; Sotriffer, C.; Evers, A.; Xiong, G.; Maser, E.
Understanding oligomerization in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: an in silico approach and evidence for an active protein
J. Biotechnol.
129
131-139
2007
Comamonas testosteroni
brenda
Mittelholzer, C.; Andersson, E.; Consten, D.; Hirai, T.; Nagahama, Y.; Norberg, B.
20 beta-hydroxysteroid dehydrogenase and CYP19A1 are differentially expressed during maturation in Atlantic cod (Gadus morhua)
J. Mol. Endocrinol.
39
319-328
2007
Gadus morhua (A8CZB9)
brenda
Sreenivasulu, G.; Senthilkumaran, B.
New evidences for the involvement of 20beta-hydroxysteroid dehydrogenase in final oocyte maturation of air-breathing catfish
Gen. Comp. Endocrinol.
163
259-269
2009
Clarias gariepinus
brenda
Tokarz, J.; Mindnich, R.; Norton, W.; Moeller, G.; Hrabe de Angelis, M.; Adamski, J.
Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2
Mol. Cell. Endocrinol.
349
202-213
2012
Danio rerio
brenda
Tokarz, J.; Norton, W.; Mller, G.; Hrabe de Angelis, M.; Adamski, J.
Zebrafish 20beta-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response
PLoS ONE
8
e54851
2013
Danio rerio
brenda
Zhang, B.; Zhu, D.; Hu, X.; Zhou, M.; Shang, P.; Lin, S.
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity
J. Steroid Biochem. Mol. Biol.
141
135-143
2014
Homo sapiens
brenda
Wu, Y.; Li, L.; Zhou, S.; Shen, Q.; Lin, H.; Zhu, Q.; Sun, J.; Ge, R.S.
Apigenin inhibits rat neurosteroidogenic 5alpha-reductase 1 and 3alpha-hydroxysteroid dehydrogenase
Neurochem. Int.
110
84-90
2017
Rattus norvegicus (P50170)
brenda
Vazirzadeh, A.; Guiguen, Y.
Differential expression of subunits of 20?-hydroxysteroid dehydrogenase during gametogenesis in rainbow trout (Oncorhychus mykiss)
Anim. Reprod. Sci.
184
139-148
2017
Oncorhynchus mykiss
brenda
Devendran, S.; Mendez-Garcia, C.; Ridlon, J.
Identification and characterization of a 20beta-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058
J. Lipid Res.
58
916-925
2017
Agathobaculum desmolans, Agathobaculum desmolans ATCC 43058
brenda
Tokarz, J.; Lintelmann, J.; Moeller, G.; Adamski, J.
Substrate multispecificity among 20?-hydroxysteroid dehydrogenase type 2 members
Mol. Cell. Endocrinol.
510
110822
2020
Danio rerio
brenda