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BRENDA support

Information on EC 1.1.1.53 - 3alpha(or 20beta)-hydroxysteroid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.53

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IUBMB Comments

The 3α-hydroxy group or 20β-hydroxy group of pregnane and androstane steroids can act as donor.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea

Synonyms
20beta-hsd, cortisone reductase, 3alpha-hsd/cr, 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase, 20-hydroxysteroid dehydrogenase, rodh2, 20hsd, 20beta-hsd type 2, cr/20beta-hsd, carbonyl reductase-like 20beta-hsd, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links