Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | induction of enzyme expression inliver by toxic metabolites generated by rapidly proliferating cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | Homo sapiens | first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation | alditol + NADP+ | - |
? | |
additional information | Homo sapiens | the enzyme is involved in pathogenesis of diabetic disease | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
female and male | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | increased expression of the enzyme in sinusoidal lining cells of the tumor | Homo sapiens | - |
liver | healthy and diabetic livers, enzyme expression analysis, distribution in liver, expression is increased in acute and chromic liver disease, overview | Homo sapiens | - |
macrophage | in inflamed temporal arteries | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NADPH + H+ | - |
Homo sapiens | alditol + NADP+ | - |
? | |
aldose + NADPH + H+ | first and rate-limiting step in the polyol pathway, in which reduction of glucose to sorbitol is coupled with NADPH oxidation | Homo sapiens | alditol + NADP+ | - |
? | |
additional information | the enzyme is involved in pathogenesis of diabetic disease | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alditol:NAD(P)+1oxidoreductase | - |
Homo sapiens |
aldose reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Homo sapiens |