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Synonyms
aldose reductase, akr1b10, akr1b3, akr1b, aldose reductase-like, aldose reductase-like protein, aldo-keto reductase family 1 member b1, akr1b14, aldrxv4, aldose reductase 2,
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alditol + NAD(P)+ = aldose + NAD(P)H + H+
alditol + NAD(P)+ = aldose + NAD(P)H + H+
reaction mechanism
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alditol + NAD(P)+ = aldose + NAD(P)H + H+
reaction mechanism
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alditol + NAD(P)+ = aldose + NAD(P)H + H+
mechanism, proton is donated by Tyr48 hydroxyl to the substrate
alditol + NAD(P)+ = aldose + NAD(P)H + H+
reaction mechanism, catalytic residues are Tyr48, Lys77, and His110, C-terminal loop residues Ala299, Leu300, Leu301, Ser302, Cys303 are involved in substrate and inhibitor binding
alditol + NAD(P)+ = aldose + NAD(P)H + H+
the ordered bi-bi kinetic mechanism is controlled by hinges and latches of enzyme structure, residues R268, G213, and S226 are involved
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alditol + NAD(P)+ = aldose + NAD(P)H + H+
after the catalytic event, a rearrangement of a bound ligand can trigger the opening of the safety-belt loop of G213-S226, initiating the release of the oxidized cofactor
alditol + NAD(P)+ = aldose + NAD(P)H + H+
after the hydride donation step, the positive charge in the nicotinamide head stabilizes the neutral bridge between residues D43 and L77, allowing the relaxation of the tyrosine geometry toward the substrate head and the subsequent proton donation. After this last step, Y48 recoils to a locked geometry where the D43-L77 salt bridge is formed again and completes a tight four-charge sandwich involving the D(-), L(+), Y(-), and nicotinamide(+) head
alditol + NAD(P)+ = aldose + NAD(P)H + H+
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(1S)-camphorquinone + NADPH + H+
?
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(3R,4S/3S,4R)-3,4-(cis)acetate-beta-lactam + NADPH + H+
4-hydroxyazetidine-2,3-diyl diacetate + NADP+
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screening of 19 individual yeast reductases for their effciency and enantioselectivity, overview
stereochemistry of products of the different enzymes, detailed overview
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?
(S)-1-indanol + NADPH + H+
?
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?
(S)-1-tetralol + NADPH + H+
?
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?
1-butanal + NADPH + H+
1-butanol + NADP+
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?
1-butanal + NADPH + H+
butanol + NADP+
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?
1-decanal + NADPH + H+
1-decanol + NADP+
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?
1-decanol + NADP+
decanal + NADPH + H+
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?
1-dodecanal + NADPH + H+
dodecanol + NADP+
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?
1-heptanal + NADPH + H+
heptanol + NADP+
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?
1-hexanal + NADPH + H+
1-hexanol + NADP+
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?
1-hexanal + NADPH + H+
hexanol + NADP+
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?
1-hydroxynonen-4-one + NADPH
1,4-dihydroxynon-2-ene + NADP+
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?
1-nonanal + NADPH + H+
1-nonanol + NADP+
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?
1-nonanal + NADPH + H+
nonanol + NADP+
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?
1-nonanol + NADP+
nonanal + NADPH + H+
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?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH
1-palmitoyl-2-(5-hydroxyvaleryl)sn-glycero-3-phosphocholine + NADP+
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?
1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine + NADPH + H+
? + NADP+
ALR2
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?
1-propanal + NADPH + H+
1-propanol + NADP+
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?
1-tetradecanol + NADP+
tetradecanal + NADPH + H+
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?
11-deoxyisocorticosterone + NAD(P)H
?
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?
16-ketoestrone + NADPH + H+
?
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?
2,3-bornanedione + NAD(P)H
?
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?
2,3-butanedione + NADPH + H+
?
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?
2,3-heptanedione + NADPH + H+
?
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?
2,3-hexanedione + NADPH + H+
?
2,3-pentanedione + NADPH + H+
?
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?
2,4-decadienal + NADPH + H+
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?
2,4-nonadienal + NADPH + H+
?
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?
2-D-deoxy-2-fluoro-galactose + NADPH
?
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r
2-D-deoxygalactose + NADPH
?
2-decenal + NADPH + H+
?
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?
2-deoxy-2-fluoro-galactose + NADPH + H+
?
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r
2-deoxyribose + NADPH
?
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r
2-hexenal + NADPH + H+
?
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2-nonenal + NADPH + H+
?
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?
2-phenyl-2-propenal + NADPH + H+
2-phenyl-1-propanol + NADP+
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?
20-isocortisol + NAD(P)H
?
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20alpha-hydroxyprogesterone + NADPH + H+
?
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?
20alpha-isocorticosterone + NAD(P)H
?
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?
21-dehydrocortisol + NADPH + H+
?
3,4-hexanedione + NADPH + H+
?
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?
3-deoxyglucosone + NADPH + H+
?
3-glutathionyl-4-hydroxynonanal + NADPH + H+
? + NADP+
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?
3-nitrobenzaldehyde + NADPH + H+
3-nitrobenzyl alcohol + NADP+
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?
3-pyridinecarboxaldehyde + NADPH + H+
3-pyridinemethanol + NADP+
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r
4-bromobenzaldehyde + NADPH + H+
4-bromobenzyl alcohol + NADP+
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r
4-carboxybenzaldehyde + NADPH + H+
4-carboxybenzyl alcohol + NADP+
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r
4-hydroxy-trans-2-nonenal + NADPH + H+
1,4-dihydroxynonane + NADP+
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?
4-hydroxynonenal + NADPH + H+
4-hydroxynonanol + NADP+
4-hydroxynonenal + NADPH + H+
?
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?
4-hydroxyphenylacetaldehyde + NAD(P)H
4-hydroxyphenylethyl alcohol + NAD(P)+
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4-hydroxyphenylglycolaldehyde + NAD(P)H
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?
4-nitrobenzaldehyde + NAD(P)H
4-nitrobenzyl alcohol + NAD(P)+
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzyl alcohol + NADP+
4-nitrobenzaldehyde + NADPH + H+
?
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?
4-oxonon-2-enal + NADPH + H+
1-hydroxynonen-4-one + NADP+
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?
4-pyridinecarboxaldehyde + NADPH + H+
4-pyridinemethanol + NADP+
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r
5-pregnene-3beta,20alpha-diol + NADPH
?
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?
5alpha-pregnan-20alpha-ol-3-one + NADPH + H+
?
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?
5alpha-pregnane-3beta,20alpha-diol + NADPH + H+
?
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?
8-acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one + NADPH + H+
? + NADP+
fluorogenic synthetic substrate
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?
acetaldehyde + NAD(P)H + H+
ethanol + NAD(P)+
acetaldehyde + NADPH + H+
ethanol + NADP+
acetol + NADPH
propane-1,2 diol + NADP+
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acrolein + NADPH
2-propen-1-ol + NADP+
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acrolein + NADPH + H+
2-propen-1-ol + NADP+
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alditol + NAD(P)+
aldose + NAD(P)H
aldose + NAD(P)H
alditol + NAD(P)+
aldose + NADPH + H+
alditol + NADP+
benzaldehyde + NAD(P)H
benzyl alcohol + NAD(P)+
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
benzyl alcohol + oxidized 3-acetylpyridine adenine dinucleotide + H+
benzaldehyde + reduced 3-acetylpyridine adenine dinucleotide
butyraldehyde + NAD(P)H
butanol + NAD(P)+
D-arabinose + NADPH
arabitol + NADP+
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r
D-arabinose + NADPH + H+
arabitol + NADP+
D-erythrose + NAD(P)H
erythritol + NAD(P)+
D-erythrose + NADPH + H+
?
D-fructose + NAD(P)H + H+
D-arabino-hexitol + NAD(P)+
D-fucose + NADPH
fucitol + NADP+
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r
D-galactose + NAD(P)H
dulcitol + NAD(P)+
D-galactose + NADPH + H+
?
D-galactose + NADPH + H+
D-galactitol + NADP+
D-glucose + NAD(P)H
sorbitol + NAD(P)+
D-glucose + NADPH + H+
D-sorbitol + NADP+
D-glucose + NADPH + H+
sorbitol + NADP+
D-glucose 6-phosphate + NADPH + H+
?
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r
D-glucuronate + NAD(P)H
?
D-glucuronate + NADPH
?
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?
D-glucuronate + NADPH
? + NADP+
D-glucuronolactone + NADPH
?
D-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
D-glyceraldehyde + NAD(P)H + H+
glycerol + NAD(P)+
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?
D-glyceraldehyde + NADPH + H+
glycerol + NADP+
D-lactaldehyde + NADPH + H+
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?
D-lactoaldehyde + NADPH + H+
?
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?
D-lyxose + NADPH
arabitol + NADP+
D-mannose + NAD(P)H
mannitol + NAD(P)+
D-ribose + NAD(P)H
ribitol + NAD(P)+
D-ribose + NADPH
adonitol + NADP+
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r
D-ribose + NADPH + H+
adonitol + NADP+
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?
D-ribose + NADPH + H+
D-ribitol + NADP+
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?
D-ribose 5-phosphate + NADPH
D-ribitol 5-phosphate + NADP+
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r
D-tagatose + NADPH
?
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r
D-xylose + NAD(P)H
xylitol + NAD(P)+
D-xylose + NADPH
?
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?
D-xylose + NADPH
xylitol + NADP+
D-xylose + NADPH + H+
D-xylitol + NADP+
D-xylose + NADPH + H+
xylitol + NADP+
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?
D-xylose 5-phosphate + NADPH
D-xylitol 5-phosphate + NADP+
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r
D-xylulose + NADPH + H+
D-xylitol + NADP+
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?
decanal + NAD(P)H
decanol + NAD(P)+
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?
dihydroxyacetone + NAD(P)H
glycerol + NAD(P)+
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?
DL-glyceraldehyde + NAD(P)H
glycerol + NAD(P)+
DL-glyceraldehyde + NAD(P)H + H+
glycerol + NAD(P)+
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?
DL-glyceraldehyde + NADPH
glycerol + NAD(P)+
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?
DL-glyceraldehyde + NADPH
glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
?
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?
DL-glyceraldehyde + NADPH + H+
DL-glycerol + NADP+
DL-glyceraldehyde + NADPH + H+
glycerol + NADP+
farnesal + NADPH + H+
trans,trans-farnesol + NADP+
specific substrate
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1.1.1.21 aldose reductase
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