Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbenoxolone | - |
Homo sapiens | |
epigallocatechin gallate | - |
Homo sapiens | |
glycyrrhetinic acid | - |
Homo sapiens | |
Momordica charantia extract | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | - |
cortisol + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
inflammatory cell | - |
Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
liver | highest expression | Homo sapiens | - |
ovary | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
vasculature | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD type 1 | - |
Homo sapiens |
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | dependent on | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays important roles in the development of the metabolic syndrome as well as at the interface of inflammation and obesity | Homo sapiens |