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11 beta-hydroxysteroid dehydrogenase type 1
11-beta hydroxysteroid dehydrogenase type 1
-
11-beta-HSD1 (oxidase) NADP+
-
-
11-beta-hydroxysteroid dehydrogenase type1
-
11beta hydroxysteroid dehydrogenase type 1
-
-
11beta-hydroxy steroid dehydrogenase
-
-
-
-
11beta-hydroxy steroid dehydrogenase type 2
-
11beta-hydroxysteroid dehydrogenase
11beta-hydroxysteroid dehydrogenase 1
11beta-hydroxysteroid dehydrogenase 2
11beta-hydroxysteroid dehydrogenase isoforms 1
11beta-hydroxysteroid dehydrogenase type 1
11beta-hydroxysteroid dehydrogenase type 2
11beta-hydroxysteroid dehydrogenase type I
11beta-hydroxysteroid dehydrogenase type-1
-
-
11beta-hydroxysteroid dehydrogenase-1
11beta-hydroxysteroid dehydrogenases type 1
-
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11beta-hydroxysteroid type 1 dehydrogenase
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11beta-hydroxysteroid-dehydrogenase type I
-
beta-hydroxysteroid dehydrogenase
-
-
-
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corticosteroid 11-reductase
-
-
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corticosteroid 11beta-dehydrogenase
-
-
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dehydrogenase, 11beta-hydroxy steroid
-
-
-
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hydroxysteroid (11-beta) dehydrogenase
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NAD-dependent 11-beta-hydroxysteroid dehydrogenase
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-
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NADP(+)-dependent 11beta-dehydrogenase
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NADP+-dependent 11beta-hydroxysteroid dehydrogenase 1
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type 1 11beta-hydroxysteroid dehydrogenase
11 beta-hydroxysteroid dehydrogenase type 1
-
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11 beta-hydroxysteroid dehydrogenase type 1
-
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11 beta-hydroxysteroid dehydrogenase type 1
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11-beta-HSD1
-
-
-
-
11-oxoreductase
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-
11beta-HSD
-
NAD-specific 11beta-HSD isoform type 2
11beta-HSD
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2 isoforms: 11beta-HSD1 and 11beta-HSD2
11beta-HSD
-
NAD-specific 11beta-HSD isoform type 2
11beta-HSD
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2 isoforms: 11beta-HSD1 and 11beta-HSD2
11beta-HSD
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2 isoforms: 11beta-HSD1 and 11beta-HSD2
11beta-HSD 1
-
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11beta-HSD type 1
-
-
11beta-HSD1
-
-
11beta-HSD1
-
-
654698, 656133, 656215, 656227, 656356, 657253, 667835, 667962, 668296, 668424, 668432, 668636, 669419, 669730, 670065, 670252, 670258, 670264, 688766, 691275, 691281, 691282, 697498, 697563, 697720, 698026, 698167, 699216, 700121, 700178, 700180, 700181, 701239, 701241, 701324, 739986, 740151
11beta-HSD1
-
cf. EC 1.1.1.B40, 11beta-HSD2
11beta-HSD1
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670253, 670263, 693544, 696666, 696682, 696736, 697737, 699469, 699842, 740142, 740144, 740149, 740155, 740840, 741248, 741297, 760685, 760868, 761543, 761665, 761754, 761758, 762406
11beta-HSD1
-
-
654196, 669730, 670263, 691275, 691281, 691282, 696054, 697498, 697563, 697625, 697737, 699469, 700121, 700178, 700180, 740144, 740151, 740377, 740915, 741017
11beta-HSD1
-
-
655347, 655349, 656215, 657253, 668126, 669504, 670263, 695409, 697625, 740806, 741248
11beta-HSD2
-
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11beta-hydroxysteroid dehydrogenase
-
-
11beta-hydroxysteroid dehydrogenase
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11beta-hydroxysteroid dehydrogenase
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11beta-hydroxysteroid dehydrogenase
-
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11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
-
11beta-hydroxysteroid dehydrogenase 1
-
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11beta-hydroxysteroid dehydrogenase 1
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11beta-hydroxysteroid dehydrogenase 1
-
-
11beta-hydroxysteroid dehydrogenase 1
-
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11beta-hydroxysteroid dehydrogenase 2
Q6P0H9
-
11beta-hydroxysteroid dehydrogenase 2
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11beta-hydroxysteroid dehydrogenase 2
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11beta-hydroxysteroid dehydrogenase 2
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11beta-hydroxysteroid dehydrogenase isoforms 1
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11beta-hydroxysteroid dehydrogenase isoforms 1
-
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11beta-hydroxysteroid dehydrogenase type 1
-
-
11beta-hydroxysteroid dehydrogenase type 1
-
11beta-hydroxysteroid dehydrogenase type 1
-
-
11beta-hydroxysteroid dehydrogenase type 1
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654637, 654698, 655162, 655216, 655218, 656133, 656215, 656356, 657253, 657396, 667152, 667835, 667962, 668296, 668424, 668636, 669419, 669640, 670065, 670258, 670264, 691275, 697563, 697720, 698026, 698167, 699841, 700121, 700178, 700181, 701241, 701324, 711377, 711383, 711387, 711800, 711951, 713232, 740151, 740803
11beta-hydroxysteroid dehydrogenase type 1
-
670253, 693544, 696666, 696736, 700179, 710777, 711632, 711752, 712702, 740149, 740155, 740840, 741297, 760680, 760868, 760876, 761543, 761665, 761754, 761758, 762406
11beta-hydroxysteroid dehydrogenase type 1
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11beta-hydroxysteroid dehydrogenase type 1
-
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655217, 691275, 697563, 697625, 700121, 700178, 711387, 711632, 711800, 712594, 713232, 740024, 740151, 740377
11beta-hydroxysteroid dehydrogenase type 1
-
11beta-hydroxysteroid dehydrogenase type 1
-
-
655349, 656215, 657253, 669504, 670261, 695409, 697625, 699841, 712594, 740146, 740806, 741117
11beta-hydroxysteroid dehydrogenase type 1
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11beta-hydroxysteroid dehydrogenase type 2
-
-
11beta-hydroxysteroid dehydrogenase type 2
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11beta-hydroxysteroid dehydrogenase type 2
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11beta-hydroxysteroid dehydrogenase type 2
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11beta-hydroxysteroid dehydrogenase type 2
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11beta-hydroxysteroid dehydrogenase type 2
-
-
11beta-hydroxysteroid dehydrogenase type 2
A0A1B0GWP2
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11beta-hydroxysteroid dehydrogenase type I
-
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11beta-hydroxysteroid dehydrogenase type I
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11beta-hydroxysteroid dehydrogenase type I
-
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11beta-hydroxysteroid dehydrogenase-1
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11beta-hydroxysteroid dehydrogenase-1
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11betaHSD1
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11betaHSD2
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isoform
11HSD1
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HSD1
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HSD11B1
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isoform
Hsd11B2
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isozyme 11beta-HSD1
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type 1 11beta-hydroxysteroid dehydrogenase
-
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type 1 11beta-hydroxysteroid dehydrogenase
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type 1 11beta-hydroxysteroid dehydrogenase
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type 1 11beta-hydroxysteroid dehydrogenase
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type 1 11beta-hydroxysteroid dehydrogenase
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additional information
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the enzyme belongs to the short-chain dehydrogenase/reductase superfamily
additional information
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cf. EC 1.1.1.184
additional information
the enzyme belongs to the short-chain dehydrogenase/reductase superfamily
additional information
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the enzyme belongs to the short-chain dehydrogenase/reductase superfamily
additional information
-
the enzyme belongs to the short-chain dehydrogenase/reductase superfamily
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(+)-11-dihydrooracin + NADP+
?
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-
-
-
r
1,2-dehydrocortisol + NADP+
1,2-dehydrocortisone + NADPH
-
-
-
-
r
1,2-dehydrocortisone + NADPH
1,2-dehydrocortisol + NADP+
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
11-dehydrocorticosterone + NADPH + H+
?
-
-
-
-
?
11-dehydrocorticosterone + NADPH + H+
corticosterone + NADP+
11-oxo-progesterone + NADPH + H+
11beta-hydroxyprogesterone + NADP+
11-oxotestosterone + NADPH + H+
?
-
-
-
-
?
11alpha-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + ?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + ?
-
i.e. cortisol
-
?
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17beta-dihydroxyandrost-4-ene-3-one + ?
17beta-hydroxyandrost-4-ene-3,11-dione + ?
11beta,20alpha-dihydroxypregn-4-ene-3-one + ?
20alpha-hydroxypregn-4-ene-3,11-dione + ?
11beta,20beta-dihydroxypregn-4-ene-3-one + ?
20beta-hydroxypregn-4-ene-3,11-dione + ?
11beta,21-dihydroxypregn-4-en-3,20-dione + ?
11-dehydro,21-hydroxy-pregn-4-en-3,20-dione + ?
11beta,21-dihydroxypregn-4-en-3,20-dione + NAD+
21-hydroxy-pregn-4-en-3,11,20-trione + NADH + H+
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
11beta-hydroxy-5alpha-androstane-3,17-dione + NAD+
11-keto-5alpha-androstane-3,17-dione + NADH + H+
-
-
-
?
11beta-hydroxy-pregn-4-ene-3,20-dione + ?
pregn-4-ene-3,11,20-trione + ?
11beta-hydroxyandrost-4-ene-3,17-dione + ?
androst-4-ene-3,11,17-trione + ?
11beta-hydroxyandrostenedione + NAD+
11-ketoandrostenedione + NADH + H+
-
-
-
?
11beta-hydroxyandrosterone + NAD+
11-ketoandrosterone + NADH + H+
-
-
-
?
11beta-hydroxydihydrotestosterone + NAD+
11-ketodihydrotestosterone + NADH + H+
-
-
-
?
11beta-hydroxyprogesterone + NAD+
11-ketoprogesterone + NADH + H+
-
-
-
?
11beta-hydroxytestosterone + NAD+
11-ketotestosterone + NADH + H+
-
-
-
?
11beta-hydroxytestosterone + NAD+
11-oxotestosterone + NADH + H+
-
-
-
-
?
12alpha-fluoro-11-dehydrocorticosterone + NADPH
12alpha-fluoro-corticosterone + NADP+
-
-
-
ir
15-deoxy-D12,14-prostaglandin J2 + NADPH
?
-
isozyme 11beta-HSD1
-
-
?
16alpha-methyl-1,2-dehydrocortisone + NADPH
16alpha-methyl-1,2-dehydrocortisol + NADP+
16alpha-methylcortisol + NADP+
16alpha-methylcortisone + NADPH
-
-
-
?
16alpha-methylcortisone + NADPH
16alpha-methylcortisol + NADP+
16beta-methylcortisol + NADP+
16beta-methylcortisone + NADPH
-
-
-
?
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH
11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+
17alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione + NADPH
11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione + NADP+
-
i.e. prednisone
i.e. prednisolone
?
2 7-oxocholesterol + 2 NADPH + 2 H+
7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+
-
40% and 60%, respectively, in lysates of HEK-293 cells and intact HEK-293 cells expressing 11beta-HSD1
-
r
2,3-benzoylphenyl-propanoic acid + NADPH
2,3-benzoylphenyl-propanol + NADP+
20alpha-hydroxypregn-4-ene-3-one + ?
20alpha-hydroxypregn-4-ene-3,11-dione + ?
21-deoxycortisol + NAD+
21-deoxycortisone + NADH + H+
-
-
-
?
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
4-methylnitrosamine-1-(3-pyridiyl)-1-butanone + NADPH
4-methylnitrosamine-1-(3-pyridiyl)-1-butanol + NADP+
-
-
-
-
?
4-methylnitrosamino-1-(3-pyridyl)-1-butanone + NADPH
4-methylnitrosamino-1-(3-pyridyl)-1-butanol + NADP+
-
i.e. NNK, genotoxic compound from tobacco smoke, isozyme 11beta-HSD1, carbonyl reductase activity, EC 1.1.1.184
-
-
r
4-nitroacetophenone + NADPH + H+
?
-
-
-
-
?
4-nitrobenzaldehyde + NADPH + H+
?
-
-
-
-
?
5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulfonyl)phenyl-2-(5H-furanone)-lactol + NADP+
5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulfonyl)phenyl-2-(5H-furanone)-lactone + NADPH
5alpha-androstane-3beta,7alpha,17beta-triol + NADP+
5alpha-androstane-3beta,7beta,17beta-triol + NADPH
-
interconversion of 7alpha to 7beta isoform, ratio Vmax/Km is 2 pmol min-1 microgramm-1/microMol
-
-
r
5alpha-androstane-3beta,7beta,17beta-triol + NADP+
5alpha-androstane-3beta,7alpha,17beta-triol + NADP
-
interconversion of 7beta to 7alpha isoform, ratio Vmax/Km is 0.5 pmol min-1 microgramm-1/microMol
-
-
r
5alpha-pregnan-11beta,17alpha-diol-3,20-dione + NAD+
5alpha-pregnan-17alpha-ol-3,11,20-trione + NADH + H+
-
-
-
?
5alpha-pregnan-3alpha,11beta,17alpha-triol-20-one + NAD+
5alpha-pregnan-3alpha,17alpha-diol-11,20-dione + NADH + H+
-
-
-
?
6-[2-(2-hydroxy-ethylamino)-ethyl]-6H-indeno[1,2-c]isoquinoline-5,11-dione + NADPH
(+)-6-[2-(2-hydroxyethyl)aminoethyl]-5-oxo-11-hydroxy-5,6-dihydro-11H-indeno[1,2-c]isoquinoline + NADP+
-
trivial name oracin, cytostatic drug, 11beta-HSD 1 exhibits enzyme cooperativity for the formation of both hydroxy-enantiomers
24% (+)-stereoisomer
-
?
6-[2-(2-hydroxy-ethylamino)-ethyl]-6H-indeno[1,2-c]isoquinoline-5,11-dione + NADPH + H+
(-)-6-[2-(2-hydroxyethyl)aminoethyl]-5-oxo-11-hydroxy-5,6-dihydro-11H-indeno[1,2-c]isoquinoline + NADP+
-
trivial name oracin, cytostatic drug
76% (-)-stereoisomer
-
?
7-keto,25-hydroxycholesterol + NADPH + H+
7beta,25-dihydroxycholesterol + NADP+
7-keto,27-hydroxycholesterol + NADP+
7beta,27-dihydroxycholesterol + NADPH + H+
the reaction is catalyzed by isoform 11beta-HSD1
-
-
r
7-ketocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
7-ketodehydroepiandrosterone + 2 NADPH + 2 H+
7alpha-hydroxydehydroepiandrosterone + 7beta-hydroxydehydroepiandrosterone + 2 NADP+
-
-
formation of alpha- and beta-product in almost equal amounts. In presence of hexose-6-phosphate dehydrogenase, the 7keto-substrate is almost fully metabolized and the 7beta-product is preferentially formed
-
?
7-oxo-5alpha-androstane-3beta,17beta-diol + NADPH
5alpha-androstane-3beta,7alpha,17beta-triol + 5alpha-androstane-3beta,7alpha,17beta-triol + NADP+
-
-
-
-
r
7-oxo-cholesterol + NADP+
7beta-hydroxycholesterol + NADPH + H+
7-oxocholesterol + NADPH + H+
7alpha-hydroxycholesterol + NADP+
-
-
-
-
?
7-oxocholesterol + NADPH + H+
7beta-hydroxycholesterol + NADP+
7-oxolithocholic acid + NADPH + H+
?
-
-
-
-
?
7alpha-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
in lysates of HEK-293 cells expressing 11beta-HSD1, no oxidation in intact HEK293 cells expressing 11beta-HSD1
-
-
r
7alpha-hydroxydehydroepiandrosterone + NADP+
7beta-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH
-
-
in presence of hexose-6-phosphate dehydrogenase, less substrate is metabolized and accumulation of 7-ketodehydroepiandrosterone is abolished
-
?
7beta,25-dihydroxycholesterol + NAD+
7-keto,25-hydroxycholesterol + NADH + H+
7beta,27-dihydroxycholesterol + NADH + H+
7-keto,27-hydroxycholesterol + NAD+
the reaction is catalyzed by isoform 11beta-HSD2
-
-
r
7beta-hydroxycholesterol + NADP+
7-oxocholesterol + NADPH
7beta-hydroxycholesterol + NADPH + H+
7-oxo-cholesterol + NADP+
-
-
-
-
r
7beta-hydroxydehydroepiandrosterone + NADP+
7alpha-hydroxydehydroepiandrosterone + 7-ketodehydroepiandrosterone + NADPH
-
-
formation of products in almost equal amounts. In presence of hexose-6-phosphate dehydrogenase, less substrate is metabolized and accumulation of 7-ketodehydroepiandrosterone is abolished
-
?
9alpha-fluoro-11-oxoprogesterone + NADPH
9alpha-fluoro-11beta-hydroxyprogesterone + NADP+
-
-
-
ir
9alpha-fluorocortisone + NADPH
9alpha-fluorocortisol + NADP+
androst-4-ene-3,11,17-trione + NADPH
11beta-hydroxyandrost-4-ene-3,17-dione + NADP+
androstenedione + NADPH + H+
testosterone + NADP+
bupropion + NADPH + H+
threohydrobupropion
-
-
-
-
?
cholestane-3beta,5alpha,6beta-triol + NAD(P)+
6-oxocholestan-3beta,5alpha-diol + NAD(P)H + H+
-
-
-
?
corticosterone + NAD+
11-dehydrocorticosterone + NADH + H+
corticosterone + NADP+
11-dehydrocorticosterone + NADPH
corticosterone + NADP+
11-dehydrocorticosterone + NADPH + H+
corticosterone + NADP+
?
-
-
-
-
?
corticosterone + NADPH + H+
?
-
-
-
-
?
corticosterone + NADPH + H+
corticosterol + NADP+
cortisol + NAD+
cortisone + NADH
cortisol + NAD+
cortisone + NADH + H+
cortisol + NADP+
cortisone + NADPH
cortisol + NADP+
cortisone + NADPH + H+
cortisone + NAD(P)H
cortisol + NAD(P)+
cortisone + NADH + H+
cortisol + NAD+
cortisone + NADPH + H+
cortisol + NADP+
dehydrocorticosterone + NADPH
corticosterone + NADP+
dexamethasone + NADP+
11-dehydromethasone + NADPH
DFU-lactol + NADPH + H+
?
-
-
-
-
?
itrosamineketone + NADPH + H+
?
-
-
-
-
?
ketoprofen + NADPH + H+
?
-
-
-
-
?
metapyrone + NADPH + H+
7alpha-hydroxycholesterol + NADP+
-
-
-
-
r
metyrapone + NADPH
? + NADP+
-
-
-
r
metyrapone + NADPH + H+
7alpha-hydroxycholesterol + NADP+
-
-
-
-
?
oracin + NADPH + H+
11-dihydrooracin + NADP+
1.1.1.146 11beta-hydroxysteroid dehydrogenase
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