Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | Mus musculus | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | Homo sapiens | isozyme 11beta-HSD1 | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | Mus musculus | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 | cortisol + NADP+ | - |
? | |
additional information | Mus musculus | local amplification of glucocorticoids by isozyme 11beta-HSD1 promotes macrophage phagocytosis of apoptotic leukocytes | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
11beta-HSD1 | - |
Mus musculus | - |
male C75BL/6 mice, 11beta-HSD1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | activity occurs after differentiation of neutrophils to macrophages | Homo sapiens | - |
macrophage | derived from bone-marrow, peritoneal macrophages, expression of isozyme 11beta-HSD1, not isozyme 11beta-HSD2 | Mus musculus | - |
additional information | no activity in polymorphonuclear cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Mus musculus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | isozyme 11beta-HSD1 | Homo sapiens | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | isozyme 11beta-HSD1 | Homo sapiens | cortisol + NADP+ | - |
? | |
additional information | local amplification of glucocorticoids by isozyme 11beta-HSD1 promotes macrophage phagocytosis of apoptotic leukocytes | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11 beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11 beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens |