Disease on EC 7.6.2.11 - ABC-type polyamine transporter
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Carcinogenesis
Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278.
Carcinoma, Hepatocellular
Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro.
Hypertension
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.
Infections
Functional characterization of murB-potABCD operon for polyamine uptake and peptidoglycan synthesis in Streptococcus suis.
Infections
Polyamine transport in human promyelocytic leukemia cells and polymorphonuclear leukocytes.
Leukemia
Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells.
Melanoma
Harnessing the polyamine transport system to treat BRAF inhibitor-resistant melanoma.
Melanoma, Experimental
Paraquat is not accumulated in B16 tumor cells by the polyamine transport system.
Meningitis, Bacterial
Computational approaches to identify common subunit vaccine candidates against bacterial meningitis.
Neoplasms
(99m)Tc-HYNIC-spermine for imaging polyamine transport system-positive tumours: preclinical evaluation.
Neoplasms
(Z)-1,4-diamino-2-butene as a vector of boron, fluorine, or iodine for cancer therapy and imaging: synthesis and biological evaluation.
Neoplasms
A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment.
Neoplasms
Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.
Neoplasms
Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives.
Neoplasms
Ant 4,4, a polyamine-anthracene conjugate, induces cell death and recovery in human promyelogenous leukemia cells (HL-60).
Neoplasms
Clickable polyamine derivatives as chemical probes for the polyamine transport system.
Neoplasms
Development of Polyamine Transport Ligands with Improved Metabolic Stability and Selectivity against Specific Human Cancers.
Neoplasms
Evaluation of Polyamine Transport Inhibitors in a Drosophila Epithelial Model Suggests the Existence of Multiple Transport Systems.
Neoplasms
F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity.
Neoplasms
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
Neoplasms
Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage.
Neoplasms
N-Benzylpolyamines as vectors of boron and fluorine for cancer therapy and imaging: synthesis and biological evaluation.
Neoplasms
Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
Neoplasms
Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles.
Neoplasms
Polyamine-blocking therapy reverses immunosuppression in the tumor microenvironment.
Neoplasms
Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase II? and II?.
Neoplasms
Polyaminoquinoline iron chelators for vectorization of antiproliferative agents: design, synthesis, and validation.
Neoplasms
Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system.
Neoplasms
Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect.
Neoplasms
Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.
Neoplasms
Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy.
Neoplasms
Synthesis and biological properties of Quilamines II, new iron chelators with antiproliferative activities.
Neoplasms
Targeting the Polyamine Transport System with Benzazepine- and Azepine-Polyamine Conjugates ().
Neoplasms
The antitumor drug F14512 enhances cisplatin and ionizing radiation effects in head and neck squamous carcinoma cell lines.
Neoplasms
The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer.
Neuroblastoma
Characterization of the polyamine transport system in mouse neuroblastoma cells. Effects of sodium and system A amino acids.
Ovarian Neoplasms
Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
Prostatic Neoplasms
Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives.
Pulmonary Arterial Hypertension
ATP13A3 is a major component of the enigmatic mammalian polyamine transport system.
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