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Information on EC 6.3.2.5 - phosphopantothenate-cysteine ligase (CTP)

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IUBMB Comments
A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC 6.3.2.51, which requires ATP. Cysteine can be replaced by some of its derivatives.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
coupling enzyme, phosphopantothenoylcysteine synthetase, ppc synthetase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
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