Protein Variants | Comment | Organism |
---|---|---|
additional information | mutation in dPPCS impair female fecundity and fertility, and disrupts the organization of the somatic and germ line cells, affects F-actin organization and results in abnormal PtdIns(4,5)P2 localization. Improper cell organization coincides with aberrant localization of the membrane molecules Gurken (Grk) and Notch, whose activities are required for specification of the follicle cells that pattern the eggshell. Mutations in dPPCS also induce alterations in scutellar patterning and cause wing vein abnormalities, phenotype, detailed overview | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + (R)-4'-phosphopantothenate + L-cysteine | Drosophila melanogaster | the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
oocyte | - |
Drosophila melanogaster | - |
ovary | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + (R)-4'-phosphopantothenate + L-cysteine | - |
Drosophila melanogaster | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? | |
CTP + (R)-4'-phosphopantothenate + L-cysteine | the enzyme is required for various processes that occur during oogenesis including chorion patterning, e.g. for F-actin remodeling during cytoplasmic dumping, overview | Drosophila melanogaster | CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphopantothenoylcysteine synthetase | - |
Drosophila melanogaster |
PPCS | - |
Drosophila melanogaster |