show all | hide all No of entries

Information on EC 6.3.2.35 - D-alanine-D-serine ligase

for references in articles please use BRENDA:EC6.3.2.35
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The product of this enzyme, D-alanyl-D-serine, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4, D-alanine---D-alanine ligase. The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Specify your search results
Select one or more organisms in this record:
Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
vanc2, vanc2/3, vangcar, d-alanine:d-serine ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-alanine + D-serine + ATP = D-alanyl-D-serine + ADP + phosphate
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
Select items on the left to see more content.