Disease on EC 4.6.1.16 - tRNA-intron lyase
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DISEASE 
TITLE OF PUBLICATION
LINK TO PUBMED
Carcinoma, Hepatocellular
Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability.
Carcinoma, Hepatocellular
Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration.
Choriocarcinoma
HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.
Coinfection
Phage T4 SegB protein is a homing endonuclease required for the preferred inheritance of T4 tRNA gene region occurring in co-infection with a related phage.
Decompression Sickness
Conformational changes and cleavage by the homing endonuclease I-PpoI: a critical role for a leucine residue in the active site.
Fetal Death
HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death.
Hepatitis B
Autophagy restricts mitochondrial DNA damage-induced release of ENDOG (endonuclease G) to regulate genome stability.
Infections
Better late than early: delayed translation of intron-encoded endonuclease I-TevI is required for efficient splicing of its host group I intron.
Infertility
Comparison of Model Predictions and Laboratory Observations of Transgene Frequencies in Continuously-Breeding Mosquito Populations.
Leprosy
Characterization of Mycobacterium leprae RecA intein, a LAGLIDADG homing endonuclease, reveals a unique mode of DNA binding, helical distortion, and cleavage compared with a canonical LAGLIDADG homing endonuclease.
Malaria
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito.
Malaria
A synthetic sex ratio distortion system for the control of the human malaria mosquito.
Microcephaly
Autosomal-Recessive Mutations in the tRNA Splicing Endonuclease Subunit TSEN15 Cause Pontocerebellar Hypoplasia and Progressive Microcephaly.
Nervous System Diseases
CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.
Retinitis Pigmentosa
Toward genome editing in X-linked RP-development of a mouse model with specific treatment relevant features.
trna-intron lyase deficiency
HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death.
Tuberculosis
In vitro splicing of erythropoietin by the Mycobacterium tuberculosis RecA intein without substituting amino acids at the splice junctions.
Tuberculosis
Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activity.
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