Reference on EC 3.1.27.10 - rRNA endonuclease

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Endo, Y.; Wool, I.G.
The site of action of alpha-sarcin on eukaryotic ribosomes. The sequence at the alpha-sarcin cleavage site in 28 S ribosomal ribonucleic acid
J. Biol. Chem.
257
9054-9060
1982
Aspergillus giganteus
Manually annotated by BRENDA team
Endo, Y.; Huber, P.W.; Wool, I.G.
The ribonuclease activity of the cytotoxin alpha-sarcin. The characteristics of the enzymatic activity of alpha-sarcin with ribosomes and ribonucleic acids as substrates
J. Biol. Chem.
258
2662-2667
1983
Aspergillus giganteus
Manually annotated by BRENDA team
Wool, I.G.
The mechanism of the action of the cytotoxic nuclease alpha-sarcin and its use to analyze ribosome structure
Trends Biochem. Sci.
9
14-17
1984
Aspergillus giganteus
-
Manually annotated by BRENDA team
Stirpe, F.; Bailey, S.; Miller, S.P.; Bodley, J.W.
Modification of ribosomal RNA by ribosome-inactivating proteins from plants
Nucleic Acids Res.
16
1349-1357
1988
Aspergillus giganteus
Manually annotated by BRENDA team
Ling, J.; Liu, W.; Wang, T.P.
Cleavage of supercoiled double-stranded DNA by several ribosome-inactivating proteins in vitro
FEBS Lett.
345
143-146
1994
Aspergillus giganteus
Manually annotated by BRENDA team
Gasset, M.; Mancheno, J.M.; Laynez, J.; Lacadena, J.; Fernandez-Ballester, G.; Martinez del Pozo, A.; Onaderra, M.; Gavilanes, J.G.
Thermal unfolding of the cytotoxin alpha-sarcin: phospholipid binding induces destabilization of the protein structure
Biochim. Biophys. Acta
1252
126-134
1995
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Lacadena, J.; Mancheno, J.M.; Martinez-Ruiz, A.; Martinez del Pozo, A.; Gasset, M.; Onaderra, M.; Gavilanes, J.G.
Substitution of histidine-137 by glutamine abolishes the catalytic activity of the ribosome-inactivating protein alpha-sarcin
Biochem. J.
309
581-586
1995
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Campos-Olivas, R.; Bruix, M.; Santoro, J.; Martinez del Pozo, A.; Lacadena, J.; Gavilanes, J.G.; Rico, M.
Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease alpha-sarcin
FEBS Lett.
399
163-165
1996
Aspergillus giganteus
Manually annotated by BRENDA team
Cheung, J.I.; Wang, Y.R.; Lin, A.
Substrate specificity of monomeric and dimeric alpha-sarcin
FEBS Lett.
386
60-64
1996
Aspergillus giganteus
Manually annotated by BRENDA team
Sylvester, I.D.; Roberts, L.M.; Lord, J.M.
Characterization of prokaryotic recombinant Aspergillus ribotoxin alpha-sarcin
Biochim. Biophys. Acta
1358
53-60
1997
Aspergillus giganteus
Manually annotated by BRENDA team
Hao, J.J.; Xu, Y-z.; Geng, C.d.; Liu, W.Y.; Wang, E.d; Gong, Z.z.; Ulbrich, N.
Purification of alpha-sarcin and an antifungal protein from Aspergillus giganteus by blue sepharose CL-6B affinity chromatography
Protein Expr. Purif.
14
295-301
1998
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Lacadena, J.; Martinez del Pozo, A.; Lacadena, V.; Martinez-Ruiz, A.; Mancheno, J.M.; Onaderra, M.; Gavilanes, J.G.
The cytotoxin alpha-sarcin behaves as a cyclizing ribonuclease
FEBS Lett.
424
46-48
1998
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Perez-Canadillas, J.M.; Campos-Olivas, R.; Lacadena, J.; Martinez del Pozo, A.; Gavilanes, J.G.; Santoro, J.; Rico, M.; Bruix, M.
Characterization of pKa values and titration shifts in the cytotoxic ribonuclease alpha-sarcin by NMR. Relationship between electrostatic interactions, structure, and catalytic function
Biochemistry
37
15865-15876
1998
Aspergillus giganteus
Manually annotated by BRENDA team
Lacadena, J.; Martinez del Pozo, A.; Martinez-Ruiz, A.; Perez-Canadillas, J.M.; Bruix, M.; Mancheno, J.M.; Onaderra, M.; Gavilanes, J.G.
Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin alpha-sarcin
Proteins
37
474-484
1999
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Hwu, L.; Huang, K.; Chen, D.; Lin, A.
The action mode of the ribosome-inactivating protein alpha-sarcin
J. Biomed. Sci.
7
420-428
2000
Aspergillus giganteus
Manually annotated by BRENDA team
Perez-Canadillas, J.M.; Santoro, J.; Campos-Olivas, R.; Lacadena, J.; Martinez del Pozo, A.; Gavilanes, J.G.; Rico, M.; Bruix, M.
The highly refined solution structure of the cytotoxic ribonuclease alpha-sarcin reveals the structural requirements for substrate recognition and ribonucleolytic activity
J. Mol. Biol.
299
1061-1073
2000
Aspergillus giganteus (P00655)
Manually annotated by BRENDA team
Xu, Y.Z.; Liu, W.Y.
Effects of the active aldehyde group generated by RNA N-glycosidase in the sarcin/ricin domain of rat 28S ribosomal RNA on peptide elongation
Biol. Chem.
381
113-119
2000
Aspergillus giganteus
Manually annotated by BRENDA team
Masip, M.; Lacadena, J.; Mancheno, J.M.; Onaderra, M.; Martinez-Ruiz, A.; Martinez del Pozo, A.; Gavilanes, J.G.
Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin alpha-sarcin
Eur. J. Biochem.
268
6190-6196
2001
Aspergillus giganteus
Manually annotated by BRENDA team
Olmo, N.; Turnay, J.; Gonzalez de Buitrago, G.; Lopez de Silanes, I.; Gavilanes, J.G.; Lizarbe, M.A.
Cytotoxic mechanism of the ribotoxin alpha-sarcin. Induction of cell death via apoptosis
Eur. J. Biochem.
268
2113-2123
2001
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Garcia-Ortega, L.; Masip, M.; Mancheno, J.M.; Onaderra, M.; Lizarbe, M.A.; Garcia-Mayoral, M.F.; Bruix, M.; Martinez del Pozo, A.; Gavilanes, J.G.
Deletion of the NH2-terminal beta-hairpin of the ribotoxin alpha-sarcin produces a nontoxic but active ribonuclease
J. Biol. Chem.
277
18632-18639
2002
Aspergillus giganteus (P00655)
Manually annotated by BRENDA team
Larsson, S.L.; Sloma, M.S.; Nygard, O.
Conformational changes in the structure of domains II and V of 28S rRNA in ribosomes treated with the translational inhibitors ricin or alpha-sarcin
Biochim. Biophys. Acta
1577
53-62
2002
Aspergillus giganteus
Manually annotated by BRENDA team
Liu, R.s.; Huang, H.; Yang, Q.; Liu, W.Y.
Purification of alpha-sarcin and an antifungal protein from mold (Aspergillus giganteus) by chitin affinity chromatography
Protein Expr. Purif.
25
50-58
2002
Aspergillus giganteus, Aspergillus giganteus MDH 18894
Manually annotated by BRENDA team
Masip, M.; Garcia-Ortega, L.; Olmo, N.; Garcia-Mayoral, M.F.; Perez-Canadillas, J.M.; Bruix, M.; Onaderra, M.; Martinez del Pozo, A.; Gavilanes, J.G.
Leucine 145 of the ribotoxin alpha-sarcin plays a key role for determining the specificity of the ribosome-inactivating activity of the protein
Protein Sci.
12
161-169
2003
Aspergillus giganteus
Manually annotated by BRENDA team
Perez-Canadilllas, J.M.; Garcia-Mayoral, M.F.; Laurents, D.V.; Martinez del Pozo, A.; Gavilanes, J.G.; Rico, M.; Bruix, M.
Tautomeric state of alpha-sarcin histidines. Ndelta tautomers are a common feature in the active site of extracellular microbial ribonucleases
FEBS Lett.
534
197-201
2003
Aspergillus giganteus
Manually annotated by BRENDA team
Garcia-Mayoral, M.F.; Pantoja-Uceda, D.; Santoro, J.; Martinez del Pozo, A.; Gavilanes, J.G.; Rico, M.; Bruix, M.
Refined NMR structure of alpha-sarcin by 15N-1H residual dipolar couplings
Eur. Biophys. J.
34
1057-1065
2005
Aspergillus giganteus
Manually annotated by BRENDA team
Korennykh, A.V.; Piccirilli, J.A.; Correll, C.C.
The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins
Nat. Struct. Mol. Biol.
13
436-443
2006
Aspergillus restrictus
Manually annotated by BRENDA team
Petyuk, V.A.; Serikov, R.N.; Vlassov, V.V.; Zenkova, M.A.
Hybridization of antisense oligonucleotides with alpha-sarcin loop region of Escherichia coli 23S rRNA
Nucleosides Nucleotides Nucleic Acids
23
895-906
2004
Escherichia coli
Manually annotated by BRENDA team
Jandhyala, D.M.; Ahluwalia, A.; Obrig, T.; Thorpe, C.M.
ZAK: a MAP3Kinase that transduces Shiga toxin and ricin induced proinflammatory cytokine expression
Cell. Microbiol.
10
1468-1477
2008
Escherichia coli
Manually annotated by BRENDA team
Alvarez-Garcia, E.; Martinez-del-Pozo, A.; Gavilanes, J.G.
Role of the basic character of alpha-sarcins NH2-terminal beta-hairpin in ribosome recognition and phospholipid interaction
Arch. Biochem. Biophys.
481
37-44
2009
Fungi
Manually annotated by BRENDA team
Alvarez-Garcia, E.; Garcia-Ortega, L.; Verdun, Y.; Bruix, M.; Martinez del Pozo, A.; Gavilanes, J.G.
Tyr-48, a conserved residue in ribotoxins, is involved in the RNA-degrading activity of alpha-sarcin
Biol. Chem.
387
535-541
2006
Aspergillus giganteus (P00655)
Manually annotated by BRENDA team
Alvarez-Garcia, E.; Alegre-Cebollada, J.; Batanero, E.; Monedero, V.; Perez-Martinez, G.; Garcia-Fernandez, R.; Gavilanes, J.G.; Martinez Del Pozo, A.
Lactococcus lactis as a vehicle for the heterologous expression of fungal ribotoxin variants with reduced IgE-binding affinity
J. Biotechnol.
134
1-8
2008
Lactococcus lactis, Lactococcus lactis MG1363
Manually annotated by BRENDA team
Herrero-Galan, E.; Lacadena, J.; Martinez Del Pozo, A.; Boucias, D.G.; Olmo, N.; Onaderra, M.; Gavilanes, J.G.
The insecticidal protein hirsutellin A from the mite fungal pathogen Hirsutella thompsonii is a ribotoxin
Proteins
72
217 - 228
2008
Aspergillus giganteus (P00655)
Manually annotated by BRENDA team
Alford, S.; Pearson, J.; Carette, A.; Ingham, R.; Howard, P.
alpha-Sarcin catalytic activity is not required for cytotoxicity
BMC Biochem.
10
9-9
2009
Aspergillus giganteus
Manually annotated by BRENDA team
Garcia-Ortega, L.; Alvarez-Garcia, E.; Gavilanes, J.G.; Martinez-Del-Pozo, A.; Joseph, S.
Cleavage of the sarcin-ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
Nucleic Acids Res.
38
4108-4119
2010
Aspergillus giganteus
Manually annotated by BRENDA team
Alford, S.C.; OSullivan, C.; Obst, J.; Christie, J.; Howard, P.L.
Conditional protein splicing of alpha-sarcin in live cells
Mol. Biosyst.
10
831-837
2014
Aspergillus giganteus
Manually annotated by BRENDA team
Carreras-Sangra, N.; Tome-Amat, J.; Garcia-Ortega, L.; Batt, C.A.; Onaderra, M.; Martinez-del-Pozo, A.; Gavilanes, J.G.; Lacadena, J.
Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin alpha-sarcin
Protein Eng. Des. Sel.
25
425-435
2012
Aspergillus giganteus, Aspergillus giganteus MDH18894
Manually annotated by BRENDA team
He, K.; Zhou, H.R.; Pestka, J.J.
Mechanisms for ribotoxin-induced ribosomal RNA cleavage
Toxicol. Appl. Pharmacol.
265
10-18
2012
Aspergillus giganteus
Manually annotated by BRENDA team