Information on EC 3.1.2.31 - dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase

for references in articles please use BRENDA:EC3.1.2.31
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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
3.1.2.31
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RECOMMENDED NAME
GeneOntology No.
dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
dihydromonacolin L-[lovastatin nonaketide synthase] + H2O = holo-[lovastatin nonaketide synthase] + dihydromonacolin L acid
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
lovastatin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
dihydromonacolin L-[lovastatin nonaketide synthase] hydrolase
Dihydromonacolin L acid is synthesized while bound to an acyl-carrier protein domain of the lovastatin nonaketide synthase (EC 2.3.1.161). Since that enzyme lacks a thioesterase domain, release of the dihydromonacolin L acid moiety from the polyketide synthase requires this dedicated enzyme.