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IUBMB CommentsConverts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly.
The enzyme appears in viruses and cellular organisms
Synonyms
flavonoid o-methyltransferase,
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flavonoid O-methyltransferase
methyltransferase, flavonoid
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F4'OMT
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flavonoid O-methyltransferase
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flavonoid O-methyltransferase
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S-adenosyl-L-methionine + apigenin = S-adenosyl-L-homocysteine + acacetin
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methyl group transfer
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para-O-methylation
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S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase
Converts apigenin into acacetin. Naringenin can also act as an acceptor, but more slowly.
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S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
S-adenosyl-L-methionine + genistein
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less than 1% activity compared to apigenin
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S-adenosyl-L-methionine + genkwanin
S-adenosyl-L-homocysteine + apigenin-7,4'-dimethyl ether
S-adenosyl-L-methionine + kaempferol
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about 10% activity compared to apigenin
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S-adenosyl-L-methionine + luteolin
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about 35% activity compared to apigenin
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S-adenosyl-L-methionine + naringenin
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less than 1% activity compared to apigenin
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S-adenosyl-L-methionine + quercetin
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about 10% activity compared to apigenin
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S-adenosyl-L-methionine + scutellarein
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about 18% activity compared to apigenin
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S-adenosyl-L-methionine + scutellarein-7-methyl ether
S-adenosyl-L-homocysteine + ladanein
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additional information
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S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone
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i.e. apigenin
i.e. acacetin
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S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone
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enzyme is involved in biosynthesis of 4'-methoxylated flavonoids
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S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
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S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
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S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
100% activity
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S-adenosyl-L-methionine + genkwanin
S-adenosyl-L-homocysteine + apigenin-7,4'-dimethyl ether
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S-adenosyl-L-methionine + genkwanin
S-adenosyl-L-homocysteine + apigenin-7,4'-dimethyl ether
about 10% activity compared to apigenin
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additional information
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no activity with baicalein, acacetin, caffeic acid, caffeoyl aldehyde, caffeoyl alcohol, 5-hydroxyconiferyl aldehyde, and 5-hydroxyconiferyl alcohol
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additional information
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no activity with baicalein, acacetin, caffeic acid, caffeoyl aldehyde, caffeoyl alcohol, 5-hydroxyconiferyl aldehyde, and 5-hydroxyconiferyl alcohol
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S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone
S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone
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enzyme is involved in biosynthesis of 4'-methoxylated flavonoids
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S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
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S-adenosyl-L-methionine + apigenin
S-adenosyl-L-homocysteine + acacetin
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additional information
not affected by Mg2+
additional information
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not affected by Mg2+
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S-adenosyl-L-homocysteine
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0.1 mM, 47% inhibition
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2-mercaptoethanol
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5 mM, required for optimum activity
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0.0521
luteolin
at pH 7.5 and 37°C
0.031
S-adenosyl-L-methionine
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0.031
apigenin
at pH 7.5 and 37°C
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0.117
apigenin
at pH 7.5 and 37°C
0.08
luteolin
at pH 7.5 and 37°C
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0.2928
luteolin
at pH 7.5 and 37°C
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7.5 - 10
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about 50% of activity maximum at pH 7.5 and 10, glycine-NaOH buffer
7.5 - 9
the enzyme shows high catalytic activity over the pH range 7.5-9.0
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UniProt
brenda
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UniProt
brenda
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brenda
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brenda
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brenda
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brenda
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A0A1X9Y2Y6_9MARC
391
0
43379
TrEMBL
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K0I7Q2_OCIBA
336
0
36840
TrEMBL
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K0ICR0_OCIBA
336
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36974
TrEMBL
Secretory Pathway (Reliability: 2)
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Ni-NTA Sefinose column chromatography
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expressed in Escherichia coli BL21(DE3) cells
expressed in Saccharomyces cerevisiae strain INVSc-1
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Kuroki, G.; Poulton, J.E.
The para-O-methylation of apigenin to acacetin by cell-free extracts of Robinia pseudoacacia L.
Z. Naturforsch. C
36c
916-920
1981
Robinia pseudoacacia
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brenda
Berim, A.; Gang, D.R.
Production of methoxylated flavonoids in yeast using ring A hydroxylases and flavonoid O-methyltransferases from sweet basil
Appl. Microbiol. Biotechnol.
102
5585-5598
2018
Ocimum basilicum (K0I7Q2), Ocimum basilicum (K0ICR0)
brenda
Liu, H.; Xu, R.X.; Gao, S.; Cheng, A.X.
The functional characterization of a site-specific apigenin 4'-O-methyltransferase synthesized by the liverwort species Plagiochasma appendiculatum
Molecules
22
759
2017
Plagiochasma appendiculatum (A0A1X9Y2Y6), Plagiochasma appendiculatum
brenda
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