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Information on EC 2.1.1.219 - tRNA (adenine57-N1/adenine58-N1)-methyltransferase

for references in articles please use BRENDA:EC2.1.1.219
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IUBMB Comments
The enzyme catalyses the formation of N1-methyladenine at two adjacent positions (57 and 58) in the T-loop of certain tRNAs (e.g. tRNAAsp). Methyladenosine at position 57 is an obligatory intermediate for the synthesis of methylinosine, which is commonly found at position 57 of archaeal tRNAs.
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The expected taxonomic range for this enzyme is: Pyrococcus abyssi
Reaction Schemes
2
+
adenine57/adenine58 in tRNA
=
2
+
N1-methyladenine57/N1-methyladenine58 in tRNA
Synonyms
pabtrmi, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + adenine57/adenine58 in tRNA = 2 S-adenosyl-L-homocysteine + N1-methyladenine57/N1-methyladenine58 in tRNA
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