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EC Tree
IUBMB Comments A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
5,6-dihydrouracil20a in tRNA
+
=
uracil20a in tRNA
+
+
5,6-dihydrouracil20b in tRNA
+
=
uracil20b in tRNA
+
+
Synonyms
Dus4p, tRNA-dihydrouridine synthase 4,
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tRNA-dihydrouridine synthase 4
-
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5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+
(1)
5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+
-
-
-
-
5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+
(2)
5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+
-
-
-
-
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tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase
A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.
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uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20a in tRNA + NAD(P)+
e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
e.g. tRNALeu(CAA) or tRNATyr
-
-
?
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uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
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-
SwissProt
brenda
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physiological function
formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast
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DUS4_SCHPO
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
326
0
37212
Swiss-Prot
other Location (Reliability: 3 )
DUS4_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
367
0
41696
Swiss-Prot
other Location (Reliability: 2 )
A0A7R8CYC9_LEPSM
336
0
37417
TrEMBL
Mitochondrion (Reliability: 4 )
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Xing, F.; Hiley, S.L.; Hughes, T.R.; Phizicky, E.M.
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs
J. Biol. Chem.
279
17850-17860
2004
Saccharomyces cerevisiae (Q06063), Saccharomyces cerevisiae
brenda
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History
1.3.1.90 tRNA-dihydrouridine20a/20b synthase [NAD(P)+]
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