Information on EC 1.3.1.90 - tRNA-dihydrouridine20a/20b synthase [NAD(P)+]

for references in articles please use BRENDA:EC1.3.1.90
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The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

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EC NUMBER
COMMENTARY hide
1.3.1.90
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RECOMMENDED NAME
GeneOntology No.
tRNA-dihydrouridine20a/20b synthase [NAD(P)+]
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,6-dihydrouracil20a in tRNA + NAD(P)+ = uracil20a in tRNA + NAD(P)H + H+
show the reaction diagram
5,6-dihydrouracil20b in tRNA + NAD(P)+ = uracil20b in tRNA + NAD(P)H + H+
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase
A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20a in tRNA + NAD(P)+
show the reaction diagram
e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
show the reaction diagram
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
uracil20a in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
show the reaction diagram
Q06063
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
uracil20b in tRNA + NAD(P)H + H+
5,6-dihydrouracil20b in tRNA + NAD(P)+
show the reaction diagram
Q06063
the enzyme specifically modifies uracil20a and uracil 20b in tRNA, e.g. tRNALeu(CAA) or tRNATyr
-
-
?
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LINKS TO OTHER DATABASES (specific for EC-Number 1.3.1.90)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)