Information on EC 1.3.1.89 - tRNA-dihydrouridine47 synthase [NAD(P)+]

for references in articles please use BRENDA:EC1.3.1.89
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The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

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EC NUMBER
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1.3.1.89
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RECOMMENDED NAME
GeneOntology No.
tRNA-dihydrouridine47 synthase [NAD(P)+]
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
5,6-dihydrouracil47 in tRNA + NAD(P)+ = uracil47 in tRNA + NAD(P)H + H+
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase
A flavoenzyme. The enzyme specifically modifies uracil47 in tRNA.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
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LITERATURE
physiological function
formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
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LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
uracil47 in tRNA + NAD(P)H + H+
5,6-dihydrouracil20 in tRNA + NAD(P)+
show the reaction diagram
the enzyme specifically modifies uracil47 in tRNA, e.g. tRNATyr
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uracil47 in tRNA + NAD(P)H + H+
5,6-dihydrouracil47 in tRNA + NAD(P)+
show the reaction diagram
e.g. tRNATyr
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
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LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
uracil47 in tRNA + NAD(P)H + H+
5,6-dihydrouracil20 in tRNA + NAD(P)+
show the reaction diagram
Q06053
the enzyme specifically modifies uracil47 in tRNA, e.g. tRNATyr
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Show AA Sequence (488 entries)
Please use the Sequence Search for a specific query.
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LINKS TO OTHER DATABASES (specific for EC-Number 1.3.1.89)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)