Information on EC 1.14.14.67 - 11-hydroxysugiol 20-monooxygenase

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The expected taxonomic range for this enzyme is: Salvia miltiorrhiza

EC NUMBER
COMMENTARY hide
1.14.14.67
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RECOMMENDED NAME
GeneOntology No.
11-hydroxysugiol 20-monooxygenase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
11-hydroxysugiol + [reduced NADPH-hemoprotein reductase] + O2 = 11,20-dihydroxysugiol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Diterpenoid biosynthesis
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
11-hydroxysugiol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (11,20-dihydroxysugiol forming)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
11-hydroxyferruginol + [reduced NADPH-hemoprotein reductase] + O2
11,20-dihydroxyferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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?
11-hydroxysugiol + [reduced NADPH-hemoprotein reductase] + O2
11,20-dihydroxysugiol + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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?
additional information
?
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enzyme hydroxylates 11-hydroxyferruginol and 11-hydroxysugiol at C-20 to give 11,20-dihydroxyferruginal and 11,20-dihydroxysugiol
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
homology modeling of structure
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae