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Information on EC 1.14.14.67 - 11-hydroxysugiol 20-monooxygenase for references in articles please use BRENDA:EC1.14.14.67
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IUBMB Comments A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11,20-dihydroxyferruginol.
The expected taxonomic range for this enzyme is: Salvia miltiorrhiza
Synonyms
CYP76AK1,
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CYP76AK1
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11-hydroxysugiol + [reduced NADPH-hemoprotein reductase] + O2 = 11,20-dihydroxysugiol + [oxidized NADPH-hemoprotein reductase] + H2O
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11-hydroxysugiol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (11,20-dihydroxysugiol forming)
A cytochrome P-450 (heme-thiolate) protein isolated from the plant Salvia miltiorrhiza (danshen). The enzyme also oxidizes 11-hydroxyferruginol to 11,20-dihydroxyferruginol.
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11-hydroxyferruginol + [reduced NADPH-hemoprotein reductase] + O2
11,20-dihydroxyferruginol + [oxidized NADPH-hemoprotein reductase] + H2O
A0A125QZE2
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11-hydroxysugiol + [reduced NADPH-hemoprotein reductase] + O2
11,20-dihydroxysugiol + [oxidized NADPH-hemoprotein reductase] + H2O
A0A125QZE2
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additional information
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A0A125QZE2
enzyme hydroxylates 11-hydroxyferruginol and 11-hydroxysugiol at C-20 to give 11,20-dihydroxyferruginal and 11,20-dihydroxysugiol
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A0A125QZE2
UniProt
brenda
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A0A125QZE2
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brenda
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homology modeling of structure
A0A125QZE2
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expression in Saccharomyces cerevisiae
A0A125QZE2
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Guo, J.; Ma, X.; Cai, Y.; Ma, Y.; Zhan, Z.; Zhou, Y.J.; Liu, W.; Guan, M.; Yang, J.; Cui, G.; Kang, L.; Yang, L.; Shen, Y.; Tang, J.; Lin, H.; Ma, X.; Jin, B.; Liu, Z.; Peters, R.J.; Zhao, Z.K.; Huang, L.
Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones
New Phytol.
210
525-534
2016
Salvia miltiorrhiza (A0A125QZE2)
brenda
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1.14.14.67 11-hydroxysugiol 20-monooxygenase
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