Information on EC 1.14.14.48 - jasmonoyl-L-amino acid 12-hydroxylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
1.14.14.48
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RECOMMENDED NAME
GeneOntology No.
jasmonoyl-L-amino acid 12-hydroxylase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a jasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2 = a 12-hydroxyjasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
jasmonoyl-L-isoleucine inactivation
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SYSTEMATIC NAME
IUBMB Comments
jasmonoyl-L-amino acid,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12-hydroxylating)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
enzyme silencing greatly enhances plant resistance to the generalist insect herbivore, Spodoptera litura
metabolism
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the enzyme plays a major regulatory role in controlling the level of jasmonyl-L-isoleucine in plants
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a jasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2
a 12-hydroxyjasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
-
-
?
a jasmonoyl-L-isoleucine + [reduced NADPH-hemoprotein reductase] + O2
a 12-hydroxyjasmonoyl-L-isoleucine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
?
jasmonoyl-L-isoleucine + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyjasmonoyl-L-isoleucine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
jasmonoyl-L-leucine + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyjasmonoyl-L-leucine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
-
-
?
jasmonoyl-L-phenylalanine + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyjasmonoyl-L-phenylalanine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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-
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?
jasmonoyl-L-valine + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyjasmonoyl-L-valine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
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?
additional information
?
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no activity with jasmonoyl-L-alanine, jasmonoyl-glycine, jasmonoyl-L-tryptophan, and jasmonoyl-1-aminocyclopropane-1-carboxylic acid
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a jasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2
a 12-hydroxyjasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
-
-
-
-
?
jasmonoyl-L-isoleucine + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyjasmonoyl-L-isoleucine + [oxidized NADPH-hemoprotein reductase] + H2O
show the reaction diagram
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Pichia pastoris
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expressed in Saccharomyces cerevisiae WAT11 cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
CYP94B3 like-1 and -2 gene transcripts are strongly induced by wounding and simulated herbivore feeding
enzyme expression is induced by wounding
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gene expression is clearly upregulated after fungal infection with Botrytis cinerea
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