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Information on EC 1.14.14.48 - jasmonoyl-L-amino acid 12-hydroxylase

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IUBMB Comments
A cytochrome P450 (heme thiolate) enzyme found in plants. The enzyme acts on jasmonoyl-L-amino acid conjugates, catalysing the hydroxylation of the C-12 position of jasmonic acid. While the best studied substrate is (+)-7-epi-jasmonoyl-L-isoleucine, the enzyme was shown to be active with jasmonoyl-L-valine and jasmonoyl-L-phenylalanine, and is likely to be active with other jasmonoyl-amino acid conjugates.
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Word Map
  • 1.14.14.48
  • jasmonate
  • cyp94c1
  • jasmonoyl-isoleucine
  • wound-inducible
  • co-receptor
  • unconjugated
  • spodoptera
  • defensive
  • necrotrophic
  • cinerea
  • phytohormone
  • planta
  • catabolite
  • 12-hydroxylation
  • hyperaccumulated
  • ja-response
  • herbivory
  • gain-of-function
  • botrytis
The enzyme appears in viruses and cellular organisms
Synonyms
CYP94B1, CYP94B3, JA-Ile 12-hydroxylase, JA-Ile-12-hydroxylase, jasmonoyl-L-isoleucine-12-hydroxylase, jasmonyl-L-isoleucine 12-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a jasmonoyl-L-amino acid + [reduced NADPH-hemoprotein reductase] + O2 = a 12-hydroxyjasmonoyl-L-amino acid + [oxidized NADPH-hemoprotein reductase] + H2O
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PATHWAY SOURCE
PATHWAYS
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