We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.13.30 leukotriene-B4 20-monooxygenase.
The expected taxonomic range for this enzyme is: Rattus norvegicus
Synonyms
leukotriene-E4 omega-hydroxylase, oxygenase, leukotriene E4 20-mono,
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
leukotriene-E4 omega-hydroxylase
-
-
-
-
oxygenase, leukotriene E4 20-mono
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + H+ + O2 = 20-hydroxyleukotriene E4 + NADP+ + H2O
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate,NADPH:oxygen oxidoreductase (20-hydroxylating)
Also acts on N-acetyl-leukotriene E4, but more slowly. Not identical with EC 1.14.13.30 leukotriene-B4 20-monooxygenase.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
leukotriene E4
omega-hydroxy-leukotriene E4
?
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
leukotriene E4
omega-hydroxy-leukotriene E4
?
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes
-
?
N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
-
-
-
?
N-acetyl-leukotriene E4 + NADPH + O2
N-acetyl-omega-hydroxy-leukotriene E4 + NADP+ + H2O
-
at a rate six times lower than leukotriene E4
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2
20-hydroxy-leukotriene E4 + NADP+ + H2O
-
metabolism of leukotriene E4 and N-acetyl-leukotriene E4 in rat liver microsomes
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
-
competitively inhibits leukotriene E4 omega-oxidation
Halothane
-
induces a transient decrease in leukotriene omega-oxidation both in vivo and in vitro, halothane metabolism-dependent trifluoracetylation of hepatic target proteins might play a role in the inactivation of the enzyme
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.08
(6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyeicosa-6,8,10,14-tetraenoate
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
additional information
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
male Sprague Dawley rats
-
-
brenda
phenobarbital-treated
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
the specific activity is about 12times lower than for liver
brenda
-
the specific activity is about 12times lower than for liver
brenda
-
-
brenda
-
highest activity
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Orning, L.
omega-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes
Eur. J. Biochem.
170
77-85
1987
Rattus norvegicus
brenda
Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro
Eur. J. Biochem.
206
869-897
1992
Rattus norvegicus
brenda
Select items on the left to see more content.
html completed
BRENDA home
History
1.14.13.34 leukotriene-E4 20-monooxygenase
more
top
