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EC 1.13.11.74 Details
show Brenda entryEC number
1.13.11.74
Accepted name
2-aminophenol 1,6-dioxygenase
Reaction
2-aminophenol + O2 = 2-aminomuconate 6-semialdehyde
Other name(s)
amnA (gene name),
amnB (gene name),
2-aminophenol:oxygen 1,6-oxidoreductase (decyclizing)
Systematic name
2-aminophenol:oxygen 1,6-oxidoreductase (ring-opening)
Comment
The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme also has some activity with 2-amino-5-methylphenol and 2-amino-4-methylphenol [1]. The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.76, 2-amino-5-chlorophenol 1,6-dioxygenase [2].
History
created 2013
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1 Oxidoreductases
1.1.1 With NAD+ or NADP+ as acceptor
1.13.11.21 created 1972, deleted 2001 1.13.12.10 created 1989, modified 1999, deleted 2001
