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EC 2.8.4.6 Details

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EC number

2.8.4.6

Accepted name

S-methyl-1-thioxylulose 5-phosphate methylthiotransferase

Reaction

S-methyl-1-thio-D-xylulose 5-phosphate + glutathione = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione

Other name(s)

1-methylthioxylulose 5-phosphate sulfurylase (incorrect)

Systematic name

S-methyl-1-thio-D-xylulose 5-phosphate:glutathione methylthiotransferase

Comment

The enzyme, characterized from the bacterium Rhodospirillum rubrum, belongs to the cupin superfamily and contains a manganese ion. It participates in an anaerobic salvage pathway that restores methionine from S-methyl-5′-thioadenosine. The enzyme was assayed in vitro using L-dithiothreitol instead of glutathione.

History

created 2021

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.11.1 Peroxidases

1.11.2 Peroxygenases

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.16.1 With NAD⁺ or NADP⁺ as acceptor

1.16.3 With oxygen as acceptor

1.16.5 With a quinone or similar compound as acceptor

1.16.8 With a flavin as acceptor

1.16.9 With a copper protein as acceptor

1.16.98 With other, known, physiological acceptors

1.16.99 With unknown physiological acceptors

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.22.1 With NAD⁺ or NADP⁺ as acceptor

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)

2 Transferases

2.1 Transferring one-carbon groups

2.2 Transferring aldehyde or ketonic groups

2.3 Acyltransferases

2.4 Glycosyltransferases

2.5 Transferring alkyl or aryl groups, other than methyl groups

2.6 Transferring nitrogenous groups

2.7 Transferring phosphorus-containing groups

2.8 Transferring sulfur-containing groups

2.8.1 Sulfurtransferases

2.8.2 Sulfotransferases

2.8.3 CoA-transferases

2.8.4 Transferring alkylthio groups

2.8.4.1 coenzyme-B sulfoethylthiotransferase

2.8.4.2 arsenate-mycothiol transferase

2.8.4.3 tRNA-2-methylthio-N⁶-dimethylallyladenosine synthase

2.8.4.4 [ribosomal protein S12] (aspartate⁸⁹-C³)-methylthiotransferase

2.8.4.5 tRNA (N⁶-L-threonylcarbamoyladenosine³⁷-C²)-methylthiotransferase

2.8.4.6 S-methyl-1-thioxylulose 5-phosphate methylthiotransferase

2.8.5 Thiosulfotransferases

2.9 Transferring selenium-containing groups

2.10 Transferring molybdenum- or tungsten-containing groups