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EC 1.7.2.7 Details

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EC number

1.7.2.7

Accepted name

hydrazine synthase

Reaction

hydrazine + H₂O + 3 ferricytochrome c = nitric oxide + ammonium + 3 ferrocytochrome c

Other name(s)

HZS

Systematic name

hydrazine:ferricytochrome-c oxidoreductase

Comment

The enzyme, characterized from anaerobic ammonia oxidizers (anammox bacteria), is one of only a few enzymes that are known to form an N-N bond (other examples include EC 1.7.1.14, nitric oxide reductase [NAD(P)⁺, nitrous oxide-forming] and EC 4.8.1.1, L-piperazate synthase). The enzyme from the bacterium Candidatus Kuenenia stuttgartiensis is a dimer of heterotrimers and contains multiple c-type cytochromes.

History

created 2016, modified 2021

EC Tree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.2 Acting on the aldehyde or oxo group of donors

1.3 Acting on the CH-CH group of donors

1.4 Acting on the CH-NH₂ group of donors

1.5 Acting on the CH-NH group of donors

1.6 Acting on NADH or NADPH

1.7 Acting on other nitrogenous compounds as donors

1.7.1 With NAD⁺ or NADP⁺ as acceptor

1.7.2 With a cytochrome as acceptor

1.7.2.1 nitrite reductase (NO-forming)

1.7.2.2 nitrite reductase (cytochrome; ammonia-forming)

1.7.2.3 trimethylamine-N-oxide reductase

1.7.2.4 nitrous-oxide reductase

1.7.2.5 nitric oxide reductase (cytochrome c)

1.7.2.6 hydroxylamine dehydrogenase

1.7.2.7 hydrazine synthase

1.7.2.8 hydrazine dehydrogenase

1.7.2.9 hydroxylamine oxidase

1.7.3 With oxygen as acceptor

1.7.5 With a quinone or similar compound as acceptor

1.7.6 With a nitrogenous group as acceptor

1.7.7 With an iron-sulfur protein as acceptor

1.7.9 With a copper protein as acceptor

1.7.99 With unknown physiological acceptors

1.8 Acting on a sulfur group of donors

1.9 Acting on a heme group of donors

1.10 Acting on diphenols and related substances as donors

1.11 Acting on a peroxide as acceptor

1.12 Acting on hydrogen as donor

1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.15 Acting on superoxide as acceptor

1.16 Oxidizing metal ions

1.17 Acting on CH or CH₂ groups

1.18 Acting on iron-sulfur proteins as donors

1.19 Acting on reduced flavodoxin as donor

1.20 Acting on phosphorus or arsenic in donors

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.22 Acting on halogen in donors

1.23 Reducing C-O-C group as acceptor

1.97 Other oxidoreductases

1.98 Enzymes using H₂ as reductant (deleted subclass)

1.99 Other enzymes using O₂ as oxidant (deleted subclass)